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• W2894090368 abstract "Cellular metabolism recently emerged as a central player modulating the bacterial cell cycle. The Alphaproteobacterium Caulobacter crescentus appears as one of the best models to study these connections, but its metabolism is still poorly characterized. Considering that it lives in oligotrophic environments, its capacity to use amino-acids is often critical for its growth. Here, we characterized the C. crescentus PutA bi-functional enzyme and showed that it is required for the utilization of proline as a carbon source. We also found that putA transcription and proline utilization by PutA are strictly dependent on the Lrp-like PutR activator. The activation of putA by PutR needs proline, which most likely acts as an effector molecule for PutR. Surprisingly, we also observed that an over-production of PutR leads to cell elongation in liquid medium containing proline, while it inhibits colony formation even in the absence of proline on solid medium. These cell division and growth defects were equally pronounced in a ΔputA mutant background, indicating that PutR can play other roles beyond the control of proline catabolism. Altogether, these findings suggest that PutR might connect central metabolism with cell cycle processes." @default.
• W2894090368 created "2018-10-05" @default.
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• W2894090368 date "2018-10-02" @default.
• W2894090368 modified "2023-10-17" @default.
• W2894090368 title "Control of proline utilization by the Lrp-like regulator PutR in Caulobacter crescentus" @default.
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• W2894090368 doi "https://doi.org/10.1038/s41598-018-32660-3" @default.
• W2894090368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168545" @default.
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• W2894090368 hasPublicationYear "2018" @default.
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