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• W2894090449 endingPage "e2004874" @default.
• W2894090449 startingPage "e2004874" @default.
• W2894090449 abstract "Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of the actin cytoskeleton and function in a physiological context in vivo remain largely obscure. It is also unknown how actin filaments generated by formins interact with other ABPs in the cell. Here, we combine genetic manipulation of formins mammalian diaphanous homolog1 (mDia1) and 3 (mDia3) with superresolution microscopy and single-molecule imaging, and show that the formins mDia1 and mDia3 are dominantly expressed in Sertoli cells of mouse seminiferous tubule and together generate a highly dynamic cortical filamentous actin (F-actin) meshwork that is continuous with the contractile actomyosin bundles. Loss of mDia1/3 impaired these F-actin architectures, induced ectopic noncontractile espin1-containing F-actin bundles, and disrupted Sertoli cell-germ cell interaction, resulting in impaired spermatogenesis. These results together demonstrate the previously unsuspected mDia-dependent regulatory mechanism of cortical F-actin that is indispensable for mammalian sperm development and male fertility." @default.
• W2894090449 created "2018-10-05" @default.
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• W2894090449 date "2018-09-26" @default.
• W2894090449 modified "2023-10-15" @default.
• W2894090449 title "mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility" @default.
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• W2894090449 cites W1973870846 @default.
• W2894090449 cites W1982408362 @default.
• W2894090449 cites W1982755401 @default.
• W2894090449 cites W1987547578 @default.
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• W2894090449 cites W1989211427 @default.
• W2894090449 cites W1990739542 @default.
• W2894090449 cites W1991549216 @default.
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• W2894090449 cites W2040679279 @default.
• W2894090449 cites W2043198887 @default.
• W2894090449 cites W2052135636 @default.
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• W2894090449 doi "https://doi.org/10.1371/journal.pbio.2004874" @default.
• W2894090449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6175529" @default.
• W2894090449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256801" @default.
• W2894090449 hasPublicationYear "2018" @default.
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