FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894091242> ?p ?o ?g. }

• W2894091242 endingPage "102" @default.
• W2894091242 startingPage "89" @default.
• W2894091242 abstract "Synaptic degeneration and neuronal loss are early events in Alzheimer’s disease (AD), occurring long before symptom onset, thus making synaptic biomarkers relevant for enabling early diagnosis. The postsynaptic protein neurogranin (Ng) is a cerebrospinal fluid (CSF) biomarker for AD, also in the prodromal phase. Here we tested the hypothesis that during AD neurodegeneration, processing of full-length Ng into endogenous peptides in the brain is increased. We characterized Ng in post-mortem brain tissue and investigated the levels of endogenous Ng peptides in relation to full-length protein in brain tissue of patients with sporadic (sAD) and familial Alzheimer’s disease (fAD), healthy controls and individuals who were cognitively unaffected but amyloid-positive (CU-AP) in two different brain regions. Brain tissue from parietal cortex [sAD (n = 10) and age-matched controls (n = 10)] and temporal cortex [sAD (n = 9), fAD (n = 10), CU-AP (n = 13) and controls (n = 9)] were included and all the samples were analyzed by three different methods. Using high-resolution mass spectrometry, 39 endogenous Ng peptides were identified while full-length Ng was found to be modified including disulfide bridges or glutathione. In sAD parietal cortex, the ratio of peptide-to-total full-length Ng was significantly increased for eight endogenous Ng peptides compared to controls. In the temporal cortex, several of the peptide-to-total full-length Ng ratios were increased in both sAD and fAD cases compared to controls and CU-AP. This finding was confirmed by western blot, which mainly detects full-length Ng, and enzyme-linked immunosorbent assay, most likely detecting a mix of peptides and full-length Ng. In addition, Ng was significantly associated with the degree of amyloid and tau pathology. These results suggest that processing of Ng into peptides is increased in AD brain tissue, which may reflect the ongoing synaptic degeneration, and which is also mirrored as increased levels of Ng peptides in CSF." @default.
• W2894091242 created "2018-10-05" @default.
• W2894091242 creator A5012836642 @default.
• W2894091242 creator A5017234848 @default.
• W2894091242 creator A5021603048 @default.
• W2894091242 creator A5025313057 @default.
• W2894091242 creator A5035827884 @default.
• W2894091242 creator A5040086950 @default.
• W2894091242 creator A5050946548 @default.
• W2894091242 creator A5062871322 @default.
• W2894091242 creator A5091785793 @default.
• W2894091242 date "2018-09-22" @default.
• W2894091242 modified "2023-10-17" @default.
• W2894091242 title "The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer’s disease" @default.
• W2894091242 cites W1208364757 @default.
• W2894091242 cites W1506302012 @default.
• W2894091242 cites W1557317938 @default.
• W2894091242 cites W1619886377 @default.
• W2894091242 cites W1807758003 @default.
• W2894091242 cites W1965661118 @default.
• W2894091242 cites W1967013632 @default.
• W2894091242 cites W1967823816 @default.
• W2894091242 cites W1968602836 @default.
• W2894091242 cites W1968857352 @default.
• W2894091242 cites W1969414063 @default.
• W2894091242 cites W1971064870 @default.
• W2894091242 cites W1974560467 @default.
• W2894091242 cites W1984652813 @default.
• W2894091242 cites W2007047564 @default.
• W2894091242 cites W2008767130 @default.
• W2894091242 cites W2015933608 @default.
• W2894091242 cites W2020054007 @default.
• W2894091242 cites W2020486984 @default.
• W2894091242 cites W2032954490 @default.
• W2894091242 cites W2034424952 @default.
• W2894091242 cites W2036963269 @default.
• W2894091242 cites W2041165019 @default.
• W2894091242 cites W2041601288 @default.
• W2894091242 cites W2052742260 @default.
• W2894091242 cites W2055361873 @default.
• W2894091242 cites W2056313099 @default.
• W2894091242 cites W2064394313 @default.
• W2894091242 cites W2064566310 @default.
• W2894091242 cites W2071148852 @default.
• W2894091242 cites W2073809577 @default.
• W2894091242 cites W2096963202 @default.
• W2894091242 cites W2105442740 @default.
• W2894091242 cites W2110774263 @default.
• W2894091242 cites W2115017507 @default.
• W2894091242 cites W2120385383 @default.
• W2894091242 cites W2124955411 @default.
• W2894091242 cites W2125633423 @default.
• W2894091242 cites W2127112728 @default.
• W2894091242 cites W2128228199 @default.
• W2894091242 cites W2135771073 @default.
• W2894091242 cites W2137813799 @default.
• W2894091242 cites W2140431554 @default.
• W2894091242 cites W21428969 @default.
• W2894091242 cites W2143461767 @default.
• W2894091242 cites W2144647267 @default.
• W2894091242 cites W2147961047 @default.
• W2894091242 cites W2156220037 @default.
• W2894091242 cites W2156326104 @default.
• W2894091242 cites W2161262899 @default.
• W2894091242 cites W2162997750 @default.
• W2894091242 cites W2165739257 @default.
• W2894091242 cites W2205427262 @default.
• W2894091242 cites W2257675936 @default.
• W2894091242 cites W2312617997 @default.
• W2894091242 cites W2407468727 @default.
• W2894091242 cites W2518545320 @default.
• W2894091242 cites W2798054687 @default.
• W2894091242 cites W2800441976 @default.
• W2894091242 cites W2888951559 @default.
• W2894091242 cites W3014251530 @default.
• W2894091242 cites W4211156109 @default.
• W2894091242 cites W57510132 @default.
• W2894091242 cites W625230187 @default.
• W2894091242 doi "https://doi.org/10.1007/s00401-018-1910-3" @default.
• W2894091242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6338696" @default.
• W2894091242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30244311" @default.
• W2894091242 hasPublicationYear "2018" @default.
• W2894091242 type Work @default.
• W2894091242 sameAs 2894091242 @default.
• W2894091242 citedByCount "59" @default.
• W2894091242 countsByYear W28940912422019 @default.
• W2894091242 countsByYear W28940912422020 @default.
• W2894091242 countsByYear W28940912422021 @default.
• W2894091242 countsByYear W28940912422022 @default.
• W2894091242 countsByYear W28940912422023 @default.
• W2894091242 crossrefType "journal-article" @default.
• W2894091242 hasAuthorship W2894091242A5012836642 @default.
• W2894091242 hasAuthorship W2894091242A5017234848 @default.
• W2894091242 hasAuthorship W2894091242A5021603048 @default.
• W2894091242 hasAuthorship W2894091242A5025313057 @default.
• W2894091242 hasAuthorship W2894091242A5035827884 @default.
• W2894091242 hasAuthorship W2894091242A5040086950 @default.
• W2894091242 hasAuthorship W2894091242A5050946548 @default.

• next