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• W2894094340 abstract "<b><i>Background:</i></b> Obstructive sleep apnea (OSA) has been linked to tumorigenesis and tumor progression. <b><i>Objectives:</i></b> The Sleep Apnea in Lung Cancer (SAIL) study (NCT02764866) was designed to determine the prevalence of OSA in patients with lung cancer. <b><i>Methods:</i></b> Cross-sectional study including consecutive patients with newly diagnosed lung cancer. All patients were offered home sleep apnea testing (HSAT) and administered a sleep-specific questionnaire prior to initiating oncologic treatment. Sleep study-related variables, symptoms, and epidemiologic data as well as cancer related variables were recorded. <b><i>Results:</i></b> Eighty-three patients were enrolled in the SAIL study. Sixty-six completed HSAT. The mean age was 68 ± 11 years and 58% were male with a mean body mass index of 28.1 ± 5.4. Forty-seven percent were current smokers, 42% former smokers, and 11% never smokers with a median tobacco consumption of 51 pack-years. Fifty percent had COPD with a mean FEV1 of 83 ± 22.6% of predicted and a mean DLCO of 85.5 ± 20.1%. Adenocarcinoma was the most common histologic type (46.7%), followed by squamous cell (16.7%) and small cell (16.7%). Most patients were diagnosed at an advanced stage (65% in stages III–IV). The vast majority (80%) had OSA (apnea-hypopnea index [AHI] &#x3e; 5), and 50% had moderate to severe OSA (AHI &#x3e; 15) with a mean Epworth Sleepiness Score of 7.43 ± 3.85. Significant nocturnal hypoxemia was common (Median T90: 10.9% interquartile range 2.4–42.2). <b><i>Conclusions:</i></b> Sleep apnea and nocturnal hypoxemia are highly prevalent in patients with lung cancer." @default.
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• W2894094340 date "2018-09-27" @default.
• W2894094340 modified "2023-10-10" @default.
• W2894094340 title "Sleep Disordered Breathing Is Highly Prevalent in Patients with Lung Cancer: Results of the Sleep Apnea in Lung Cancer Study" @default.
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• W2894094340 doi "https://doi.org/10.1159/000492273" @default.
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