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- W2894095020 abstract "Immunohistochemical evaluation of proteins of the Sonic hedgehog (Shh) signaling pathway in sporadic and syndromic odontogenic keratocyst (OKC) was performed. Clinicopathologic features of 62 patients revealed 13 patients with nevoid basal cell carcinoma syndrome (NBCCS) (29 OKC) and 49 not syndromic (57 OKC). Shh, Smo, and Gli1 proteins showed increased expression in syndromic OKCs; Shh showed intermediate cytoplasmic expression, concentrated within the basal layer of syndromic cysts. Smo showed stronger expression in the basal and suprabasal layers of syndromic OKCs, whereas Gli1 expression was higher in the cytoplasm compared with that in sporadic cysts. Standardizing a new diagnostic tool for NBCCS can facilitate early identification of therapeutic targets. Higher expression of Shh, Smo, and Gli1 in OKCs can indicate their association with NBCCS. Shh signaling pathway should be studied for understanding the biologic development of different cancers. However, activation mechanisms for this pathway remain unclear, requiring further investigation." @default.
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- W2894095020 date "2018-09-01" @default.
- W2894095020 modified "2023-10-16" @default.
- W2894095020 title "Immunohistochemical Evaluation of Shh Signaling Pathway Proteins in Sporadic and Syndromic Odontogenic Keratocyst" @default.
- W2894095020 doi "https://doi.org/10.1016/j.oooo.2018.02.056" @default.
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