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• W2894095042 abstract "LUMAN/CREB3, originally identified through its interaction with a cell cycle regulator HCFC1, is a transcription factor involved in the unfolded protein response during endoplasmic reticulum (ER) stress. Previously using gene knockout mouse models, we have shown that LUMAN modulates the glucocorticoid (GC) response leading to enhanced glucocorticoid receptor (GR) activity and lower circulating GC levels. Consequently, the central stress response system, the HPA axis, is dysregulated leading to a blunted stress response in the Luman-deficient mice. Here, we found that LUMAN interacts with GR through a putative nuclear receptor (NR) box site and can activate GR in the absence of a ligand. Further investigation showed that, when activated, LUMAN binds to the glucocorticoid response element (GRE), increasing the activity of GR exponentially compared to GR-ligand binding alone. On the other hand, we also found that in the absence of LUMAN, cells were more sensitive to cellular stress, exhibiting decreased secretory capacity. Hence our current data suggest that LUMAN may function both as a transcriptional cofactor of GR and a hormone secretion regulator, and through this, plays a role in stress sensitivity and reactivity to stress." @default.
• W2894095042 created "2018-10-05" @default.
• W2894095042 creator A5006804095 @default.
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• W2894095042 date "2018-09-26" @default.
• W2894095042 modified "2023-10-14" @default.
• W2894095042 title "LUMAN/CREB3 Plays a Dual Role in Stress Responses as a Cofactor of the Glucocorticoid Receptor and a Regulator of Secretion" @default.
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• W2894095042 doi "https://doi.org/10.3389/fnmol.2018.00352" @default.
• W2894095042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6179040" @default.
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