FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894096606> ?p ?o ?g. }

• W2894096606 endingPage "131" @default.
• W2894096606 startingPage "120" @default.
• W2894096606 abstract "Abstract Background Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage strategy to induce rapid regeneration of the remnant liver. The technique has been associated with high mortality and morbidity rates. This study aimed to evaluate mitochondrial function, biogenesis and morphology during ALPPS-induced liver regeneration. Methods Male Wistar rats (n = 100) underwent portal vein ligation (PVL) or ALPPS. The animals were killed at 0 h (without operation), and 24, 48, 72 or 168 h after intervention. Regeneration rate and proliferation index were assessed. Mitochondrial oxygen consumption and adenosine 5′-triphosphate (ATP) production were measured. Mitochondrial biogenesis was evaluated by protein level measurements of peroxisome proliferator-activated receptor γ co-activator (PGC) 1-α, nuclear respiratory factor (NRF) 1 and 2, and mitochondrial transcription factor α. Mitochondrial morphology was evaluated by electron microscopy. Results Regeneration rate and Ki-67 index were significantly raised in the ALPPS group compared with the PVL group (regeneration rate at 168 h: mean(s.d.) 291·2(21·4) versus 245·1(13·8) per cent, P &lt; 0·001; Ki-67 index at 24 h: 86·9(4·6) versus 66·2(4·9) per cent, P &lt; 0·001). In the ALPPS group, mitochondrial function was impaired 48 h after the intervention compared with that in the PVL group (induced ATP production); (complex I: 361·9(72·3) versus 629·7(165·8) nmol per min per mg, P = 0·038; complex II: 517·5(48·8) versus 794·8(170·4) nmol per min per mg, P = 0·044). Markers of mitochondrial biogenesis were significantly lower 48 and 72 h after ALPPS compared with PVL (PGC1-α at 48 h: 0·61-fold decrease, P = 0·045; NRF1 at 48 h: 0·48-fold decrease, P = 0·028). Mitochondrial size decreased significantly after ALPPS (0·26(0·05) versus 0·40(0·07) μm2; P = 0·034). Conclusion Impaired mitochondrial function and biogenesis, along with the rapid energy-demanding cell proliferation, may cause hepatocyte dysfunction after ALPPS. Surgical relevanceAssociating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a well known surgical strategy that combines liver partition and portal vein ligation. This method induces immense regeneration in the future liver remnant. The rapid volume increase is of benefit for resectability, but the mortality and morbidity rates of ALPPS are strikingly high. Moreover, lagging functional recovery of the remnant liver has been reported recently.In this translational study, ALPPS caused an overwhelming inflammatory response that interfered with the peroxisome proliferator-activated receptor γ co-activator 1-α-coordinated, stress-induced, mitochondrial biogenesis pathway. This resulted in the accumulation of immature and malfunctioning mitochondria in hepatocytes during the early phase of liver regeneration (bioenergetic destabilization).These findings might explain some of the high morbidity if confirmed in patients." @default.
• W2894096606 created "2018-10-05" @default.
• W2894096606 creator A5010421355 @default.
• W2894096606 creator A5010467141 @default.
• W2894096606 creator A5026124023 @default.
• W2894096606 creator A5028191012 @default.
• W2894096606 creator A5032996322 @default.
• W2894096606 creator A5053144324 @default.
• W2894096606 creator A5054736271 @default.
• W2894096606 creator A5056511925 @default.
• W2894096606 creator A5059015225 @default.
• W2894096606 creator A5082564607 @default.
• W2894096606 creator A5090964892 @default.
• W2894096606 date "2018-09-27" @default.
• W2894096606 modified "2023-10-09" @default.
• W2894096606 title "Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model" @default.
• W2894096606 cites W1589792898 @default.
• W2894096606 cites W191921287 @default.
• W2894096606 cites W1979809037 @default.
• W2894096606 cites W1990171977 @default.
• W2894096606 cites W1993818418 @default.
• W2894096606 cites W2001218848 @default.
• W2894096606 cites W2003011688 @default.
• W2894096606 cites W2042789770 @default.
• W2894096606 cites W2058491683 @default.
• W2894096606 cites W2071008076 @default.
• W2894096606 cites W2107324877 @default.
• W2894096606 cites W2107868887 @default.
• W2894096606 cites W2121904350 @default.
• W2894096606 cites W2126181510 @default.
• W2894096606 cites W2158088166 @default.
• W2894096606 cites W2159241159 @default.
• W2894096606 cites W2167279371 @default.
• W2894096606 cites W2172240227 @default.
• W2894096606 cites W2297849231 @default.
• W2894096606 cites W2317081003 @default.
• W2894096606 cites W2409116300 @default.
• W2894096606 cites W2532150925 @default.
• W2894096606 cites W2587371743 @default.
• W2894096606 cites W2591880537 @default.
• W2894096606 cites W2607444029 @default.
• W2894096606 cites W2738047795 @default.
• W2894096606 cites W2769659064 @default.
• W2894096606 cites W2773235180 @default.
• W2894096606 cites W4230399767 @default.
• W2894096606 doi "https://doi.org/10.1002/bjs.10978" @default.
• W2894096606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259964" @default.
• W2894096606 hasPublicationYear "2018" @default.
• W2894096606 type Work @default.
• W2894096606 sameAs 2894096606 @default.
• W2894096606 citedByCount "12" @default.
• W2894096606 countsByYear W28940966062018 @default.
• W2894096606 countsByYear W28940966062019 @default.
• W2894096606 countsByYear W28940966062020 @default.
• W2894096606 countsByYear W28940966062021 @default.
• W2894096606 countsByYear W28940966062022 @default.
• W2894096606 countsByYear W28940966062023 @default.
• W2894096606 crossrefType "journal-article" @default.
• W2894096606 hasAuthorship W2894096606A5010421355 @default.
• W2894096606 hasAuthorship W2894096606A5010467141 @default.
• W2894096606 hasAuthorship W2894096606A5026124023 @default.
• W2894096606 hasAuthorship W2894096606A5028191012 @default.
• W2894096606 hasAuthorship W2894096606A5032996322 @default.
• W2894096606 hasAuthorship W2894096606A5053144324 @default.
• W2894096606 hasAuthorship W2894096606A5054736271 @default.
• W2894096606 hasAuthorship W2894096606A5056511925 @default.
• W2894096606 hasAuthorship W2894096606A5059015225 @default.
• W2894096606 hasAuthorship W2894096606A5082564607 @default.
• W2894096606 hasAuthorship W2894096606A5090964892 @default.
• W2894096606 hasBestOaLocation W28940966061 @default.
• W2894096606 hasConcept C126322002 @default.
• W2894096606 hasConcept C134018914 @default.
• W2894096606 hasConcept C141071460 @default.
• W2894096606 hasConcept C159110652 @default.
• W2894096606 hasConcept C16685009 @default.
• W2894096606 hasConcept C170493617 @default.
• W2894096606 hasConcept C171056886 @default.
• W2894096606 hasConcept C179437574 @default.
• W2894096606 hasConcept C2776795407 @default.
• W2894096606 hasConcept C2776909242 @default.
• W2894096606 hasConcept C2777229759 @default.
• W2894096606 hasConcept C28859421 @default.
• W2894096606 hasConcept C2992208098 @default.
• W2894096606 hasConcept C55493867 @default.
• W2894096606 hasConcept C71924100 @default.
• W2894096606 hasConcept C86803240 @default.
• W2894096606 hasConcept C88045685 @default.
• W2894096606 hasConcept C95444343 @default.
• W2894096606 hasConceptScore W2894096606C126322002 @default.
• W2894096606 hasConceptScore W2894096606C134018914 @default.
• W2894096606 hasConceptScore W2894096606C141071460 @default.
• W2894096606 hasConceptScore W2894096606C159110652 @default.
• W2894096606 hasConceptScore W2894096606C16685009 @default.
• W2894096606 hasConceptScore W2894096606C170493617 @default.
• W2894096606 hasConceptScore W2894096606C171056886 @default.
• W2894096606 hasConceptScore W2894096606C179437574 @default.
• W2894096606 hasConceptScore W2894096606C2776795407 @default.
• W2894096606 hasConceptScore W2894096606C2776909242 @default.

• next