FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894101807> ?p ?o ?g. }

• W2894101807 endingPage "11" @default.
• W2894101807 startingPage "1" @default.
• W2894101807 abstract "Taraxasterol, a pentacyclic-triterpene compound, is one of the main active components isolated from the traditional Chinese medicinal herb Taraxacum. The objective of this study is to evaluate the protective effects of taraxasterol and its possible underlying mechanisms against ethanol-induced liver injury in mice. ICR mice were fed with Lieber-DeCarli diet containing 5% ethanol for 10 d and then challenged with a single dose of 20% ethanol (5 g/kg BW) by intragastric administration. The mice were intragastrically treated daily with taraxasterol (2.5, 5, and 10 mg/kg). Tiopronin was used as a positive control. The liver index was calculated, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in sera were detected. The contents of reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) and the activity of superoxide dismutase (SOD) in the livers were measured. The histopathological changes of liver tissues were observed by hematoxylin and eosin (H&E) staining. The protein expression levels of hepatic cytochrome P450 2E1 (CYP2E1), nuclear factor erythroid 2-related factor 2 (Nrf2), antioxidant protein heme oxygenase-1 (HO-1), and nuclear factor-kappa B (NF-κB) signaling pathway in liver tissues were detected by immunohistochemistry and Western blot methods. Taraxasterol significantly reduced the ethanol-induced increases of liver index, ALT, AST, and TG levels in sera and TG and MDA contents in the livers and hepatic ROS production and suppressed the ethanol-induced decreases of hepatic GSH level and SOD activity. Taraxasterol also significantly inhibited the secretion of proinflammatory cytokines TNF-α and IL-6 induced by ethanol. In addition, taraxasterol improved the liver histopathological changes in mice with ethanol-induced liver injury. Further studies revealed that taraxasterol significantly inhibited the ethanol-induced upregulation of CYP2E1, increased the ethanol-induced downregulation of Nrf2 and HO-1, and inhibited the degradation of inhibitory kappa Bα (IκBα) and the expression level of NF-κB p65 in liver tissues of ethanol-induced mice. These findings suggest that taraxasterol possesses the potential protective effects against ethanol-induced liver injury in mice by exerting antioxidative stress and anti-inflammatory response via CYP2E1/Nrf2/HO-1 and NF-κB signaling pathways." @default.
• W2894101807 created "2018-10-05" @default.
• W2894101807 creator A5022154076 @default.
• W2894101807 creator A5025996303 @default.
• W2894101807 creator A5054759174 @default.
• W2894101807 creator A5055352258 @default.
• W2894101807 creator A5077205462 @default.
• W2894101807 creator A5081424708 @default.
• W2894101807 date "2018-09-23" @default.
• W2894101807 modified "2023-10-14" @default.
• W2894101807 title "Protective Effects of Taraxasterol against Ethanol-Induced Liver Injury by Regulating CYP2E1/Nrf2/HO-1 and NF-<i>κ</i>B Signaling Pathways in Mice" @default.
• W2894101807 cites W1495200383 @default.
• W2894101807 cites W1972689229 @default.
• W2894101807 cites W1975871313 @default.
• W2894101807 cites W1981018993 @default.
• W2894101807 cites W1981280200 @default.
• W2894101807 cites W1981757729 @default.
• W2894101807 cites W1990071637 @default.
• W2894101807 cites W1990275174 @default.
• W2894101807 cites W1991004213 @default.
• W2894101807 cites W1994677358 @default.
• W2894101807 cites W1995039600 @default.
• W2894101807 cites W1996467506 @default.
• W2894101807 cites W1996666440 @default.
• W2894101807 cites W2002801265 @default.
• W2894101807 cites W2003272885 @default.
• W2894101807 cites W2010894985 @default.
• W2894101807 cites W2017730825 @default.
• W2894101807 cites W2021709462 @default.
• W2894101807 cites W2022791025 @default.
• W2894101807 cites W2024933805 @default.
• W2894101807 cites W2029578496 @default.
• W2894101807 cites W2031018138 @default.
• W2894101807 cites W2036572511 @default.
• W2894101807 cites W2057468801 @default.
• W2894101807 cites W2060148475 @default.
• W2894101807 cites W2060214284 @default.
• W2894101807 cites W2122939956 @default.
• W2894101807 cites W2124345456 @default.
• W2894101807 cites W2144312649 @default.
• W2894101807 cites W2144468748 @default.
• W2894101807 cites W2160724854 @default.
• W2894101807 cites W2247868881 @default.
• W2894101807 cites W2342750304 @default.
• W2894101807 cites W2410120869 @default.
• W2894101807 cites W2489700480 @default.
• W2894101807 cites W2556152152 @default.
• W2894101807 cites W2561242835 @default.
• W2894101807 cites W2588442940 @default.
• W2894101807 doi "https://doi.org/10.1155/2018/8284107" @default.
• W2894101807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6174809" @default.
• W2894101807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30344887" @default.
• W2894101807 hasPublicationYear "2018" @default.
• W2894101807 type Work @default.
• W2894101807 sameAs 2894101807 @default.
• W2894101807 citedByCount "96" @default.
• W2894101807 countsByYear W28941018072019 @default.
• W2894101807 countsByYear W28941018072020 @default.
• W2894101807 countsByYear W28941018072021 @default.
• W2894101807 countsByYear W28941018072022 @default.
• W2894101807 countsByYear W28941018072023 @default.
• W2894101807 crossrefType "journal-article" @default.
• W2894101807 hasAuthorship W2894101807A5022154076 @default.
• W2894101807 hasAuthorship W2894101807A5025996303 @default.
• W2894101807 hasAuthorship W2894101807A5054759174 @default.
• W2894101807 hasAuthorship W2894101807A5055352258 @default.
• W2894101807 hasAuthorship W2894101807A5077205462 @default.
• W2894101807 hasAuthorship W2894101807A5081424708 @default.
• W2894101807 hasBestOaLocation W28941018071 @default.
• W2894101807 hasConcept C126322002 @default.
• W2894101807 hasConcept C134018914 @default.
• W2894101807 hasConcept C140027455 @default.
• W2894101807 hasConcept C181199279 @default.
• W2894101807 hasConcept C185592680 @default.
• W2894101807 hasConcept C2775838275 @default.
• W2894101807 hasConcept C2776151105 @default.
• W2894101807 hasConcept C2776217839 @default.
• W2894101807 hasConcept C2776637226 @default.
• W2894101807 hasConcept C2778004101 @default.
• W2894101807 hasConcept C2778401633 @default.
• W2894101807 hasConcept C2779219270 @default.
• W2894101807 hasConcept C48349386 @default.
• W2894101807 hasConcept C526171541 @default.
• W2894101807 hasConcept C538909803 @default.
• W2894101807 hasConcept C55493867 @default.
• W2894101807 hasConcept C71924100 @default.
• W2894101807 hasConcept C86803240 @default.
• W2894101807 hasConcept C98274493 @default.
• W2894101807 hasConceptScore W2894101807C126322002 @default.
• W2894101807 hasConceptScore W2894101807C134018914 @default.
• W2894101807 hasConceptScore W2894101807C140027455 @default.
• W2894101807 hasConceptScore W2894101807C181199279 @default.
• W2894101807 hasConceptScore W2894101807C185592680 @default.
• W2894101807 hasConceptScore W2894101807C2775838275 @default.
• W2894101807 hasConceptScore W2894101807C2776151105 @default.
• W2894101807 hasConceptScore W2894101807C2776217839 @default.
• W2894101807 hasConceptScore W2894101807C2776637226 @default.
• W2894101807 hasConceptScore W2894101807C2778004101 @default.

• next