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- W2894104560 abstract "Abstract Proteins can be phosphorylated at neighboring sites resulting in different functional states, and studying the regulation of these sites has been challenging. Here we present Thesaurus, a search engine that detects new positional isomers using site-specific fragment ions from parallel reaction monitoring and data independent acquisition mass spectrometry experiments. We apply Thesaurus to analyze phosphorylation events in the PI3K/AKT signaling pathway and show neighboring sites with distinct quantitative profiles, indicating regulation by different kinases." @default.
- W2894104560 created "2018-10-05" @default.
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- W2894104560 date "2018-09-26" @default.
- W2894104560 modified "2023-10-14" @default.
- W2894104560 title "Thesaurus: quantifying phosphoprotein positional isomers" @default.
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- W2894104560 doi "https://doi.org/10.1101/421214" @default.
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