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- W2894112219 abstract "Genetic factors, especially those related to the immune systemfunctioning, have been intensively studied for their role inthe development of recurrent aphthous stomatitis (RAS). The aimof the present study was to analyze gene variability ininterleukins (ILs): IL-2, IL-4 and its receptor α (IL-4Rα),IL-10 and IL-13, which were selected based on the literaturereview and/or their functional relevance, in Czech patientswith RAS and healthy controls. Generally, 252 subjects wereenrolled in this case-control study (178 controls and 74patients with RAS) and their detail anamnestic, clinical andlaboratory data were obtained. Nine polymorphisms in the genesencoding ILs were determined by PCR techniques. There were nosignificant differences in allele or genotype frequencies ofthe studied polymorphisms IL-2 (rs2069762 and rs2069763), IL-4(rs2243250 and rs79071878), IL-4Rα (rs1801275), IL-10(rs1800896), and IL-13 (rs1800925) between the controls and RASpatients. The minority alleles of the IL-10 (rs1800871 andrs1800872) variants were associated with a higher risk of RAS(P<0.05), as confirmed by the results of genotype and haplotypeanalysis (P<0.05). We suggest that variability in the IL-10gene may play an important role in the RAS development in theCzech population." @default.
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- W2894112219 date "2018-01-01" @default.
- W2894112219 modified "2023-10-18" @default.
- W2894112219 title "Recurrent aphthous stomatitis and gene variability in selectedinterleukins" @default.
- W2894112219 hasPublicationYear "2018" @default.
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