FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894150395> ?p ?o ?g. }

• W2894150395 endingPage "184" @default.
• W2894150395 startingPage "174" @default.
• W2894150395 abstract "Objectives The human leucine-rich repeats and immunoglobulin-like domains (LRIG) protein family comprises the integral membrane proteins LRIG1, LRIG2 and LRIG3. LRIG1 is frequently down-regulated in human cancer, and high levels of LRIG1 in tumor tissue are associated with favorable clinical outcomes in several tumor types including non-small cell lung cancer (NSCLC). Mechanistically, LRIG1 negatively regulates receptor tyrosine kinases and functions as a tumor suppressor. However, the details of the molecular mechanisms involved are poorly understood, and even less is known about the functions of LRIG2 and LRIG3. The aim of this study was to further elucidate the functions and molecular interactions of the LRIG proteins. Materials and methods A yeast two-hybrid screen was performed using a cytosolic LRIG3 peptide as bait. In transfected human cells, co-immunoprecipitation and co-localization experiments were performed. Proximity ligation assay was performed to investigate interactions between endogenously expressed proteins. Expression levels of LMO7 and LIMCH1 in normal and malignant lung tissue were investigated using qRT-PCR and through in silico analyses of public data sets. Finally, a clinical cohort comprising 355 surgically treated NSCLC cases was immunostained for LMO7. Results In the yeast two-hybrid screen, the two paralogous proteins LMO7 and LIMCH1 were identified as interaction partners to LRIG3. LMO7 and LIMCH1 co-localized and co-immunoprecipitated with both LRIG1 and LRIG3. Endogenously expressed LMO7 was in close proximity of both LRIG1 and LRIG3. LMO7 and LIMCH1 were highly expressed in normal lung tissue and down-regulated in malignant lung tissue. LMO7 immunoreactivity was shown to be a negative prognostic factor in LRIG1 positive tumors, predicting poor patient survival. Conclusion These findings suggest that LMO7 and LIMCH1 physically interact with LRIG proteins and that expression of LMO7 is of clinical importance in NSCLC." @default.
• W2894150395 created "2018-10-05" @default.
• W2894150395 creator A5001810357 @default.
• W2894150395 creator A5007721075 @default.
• W2894150395 creator A5030211192 @default.
• W2894150395 creator A5052033876 @default.
• W2894150395 creator A5064553681 @default.
• W2894150395 creator A5074514816 @default.
• W2894150395 creator A5089645449 @default.
• W2894150395 creator A5091504498 @default.
• W2894150395 date "2018-11-01" @default.
• W2894150395 modified "2023-10-01" @default.
• W2894150395 title "LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease" @default.
• W2894150395 cites W1548912210 @default.
• W2894150395 cites W1964582717 @default.
• W2894150395 cites W1964969316 @default.
• W2894150395 cites W1966330733 @default.
• W2894150395 cites W1966385073 @default.
• W2894150395 cites W1970624401 @default.
• W2894150395 cites W1978181095 @default.
• W2894150395 cites W1980574728 @default.
• W2894150395 cites W2001592430 @default.
• W2894150395 cites W2007694483 @default.
• W2894150395 cites W2009268516 @default.
• W2894150395 cites W2026263665 @default.
• W2894150395 cites W2029595157 @default.
• W2894150395 cites W2044022855 @default.
• W2894150395 cites W2049969188 @default.
• W2894150395 cites W2061644007 @default.
• W2894150395 cites W2067153802 @default.
• W2894150395 cites W2067578459 @default.
• W2894150395 cites W2067683832 @default.
• W2894150395 cites W2071615558 @default.
• W2894150395 cites W2073557494 @default.
• W2894150395 cites W2074512053 @default.
• W2894150395 cites W2080205501 @default.
• W2894150395 cites W2082337923 @default.
• W2894150395 cites W2083035507 @default.
• W2894150395 cites W2087771752 @default.
• W2894150395 cites W2089937396 @default.
• W2894150395 cites W2092974902 @default.
• W2894150395 cites W2098209113 @default.
• W2894150395 cites W2099318912 @default.
• W2894150395 cites W2099540110 @default.
• W2894150395 cites W2107296273 @default.
• W2894150395 cites W2117695961 @default.
• W2894150395 cites W2124733101 @default.
• W2894150395 cites W2130881165 @default.
• W2894150395 cites W2137899535 @default.
• W2894150395 cites W2144343661 @default.
• W2894150395 cites W2156425837 @default.
• W2894150395 cites W2203213766 @default.
• W2894150395 cites W2289059000 @default.
• W2894150395 cites W2334347178 @default.
• W2894150395 cites W2591171938 @default.
• W2894150395 cites W2784132648 @default.
• W2894150395 cites W2793917889 @default.
• W2894150395 cites W4248518923 @default.
• W2894150395 doi "https://doi.org/10.1016/j.lungcan.2018.09.017" @default.
• W2894150395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30429017" @default.
• W2894150395 hasPublicationYear "2018" @default.
• W2894150395 type Work @default.
• W2894150395 sameAs 2894150395 @default.
• W2894150395 citedByCount "17" @default.
• W2894150395 countsByYear W28941503952019 @default.
• W2894150395 countsByYear W28941503952020 @default.
• W2894150395 countsByYear W28941503952021 @default.
• W2894150395 countsByYear W28941503952022 @default.
• W2894150395 countsByYear W28941503952023 @default.
• W2894150395 crossrefType "journal-article" @default.
• W2894150395 hasAuthorship W2894150395A5001810357 @default.
• W2894150395 hasAuthorship W2894150395A5007721075 @default.
• W2894150395 hasAuthorship W2894150395A5030211192 @default.
• W2894150395 hasAuthorship W2894150395A5052033876 @default.
• W2894150395 hasAuthorship W2894150395A5064553681 @default.
• W2894150395 hasAuthorship W2894150395A5074514816 @default.
• W2894150395 hasAuthorship W2894150395A5089645449 @default.
• W2894150395 hasAuthorship W2894150395A5091504498 @default.
• W2894150395 hasConcept C121608353 @default.
• W2894150395 hasConcept C142724271 @default.
• W2894150395 hasConcept C153911025 @default.
• W2894150395 hasConcept C170493617 @default.
• W2894150395 hasConcept C2776243700 @default.
• W2894150395 hasConcept C2776256026 @default.
• W2894150395 hasConcept C502942594 @default.
• W2894150395 hasConcept C54355233 @default.
• W2894150395 hasConcept C71829478 @default.
• W2894150395 hasConcept C71924100 @default.
• W2894150395 hasConcept C81885089 @default.
• W2894150395 hasConcept C86803240 @default.
• W2894150395 hasConcept C95444343 @default.
• W2894150395 hasConceptScore W2894150395C121608353 @default.
• W2894150395 hasConceptScore W2894150395C142724271 @default.
• W2894150395 hasConceptScore W2894150395C153911025 @default.
• W2894150395 hasConceptScore W2894150395C170493617 @default.
• W2894150395 hasConceptScore W2894150395C2776243700 @default.
• W2894150395 hasConceptScore W2894150395C2776256026 @default.
• W2894150395 hasConceptScore W2894150395C502942594 @default.

• next