FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894212902> ?p ?o ?g. }

• W2894212902 abstract "Aim: We investigated the underlying mechanisms in atrial fibrillation (AF) associated with R33Q mutation and Ca2+-triggered activity. Methods and Results: We examined AF susceptibility with intraesophageal burst pacing in the sarcoplasmic reticulum (SR) Ca2+ leak model calsequestrin 2 R33Q (Casq2R33Q/R33Q) mice. Atrial trigger appeared in R33Q mice but not WT mice (17.24%, 5/29 vs. 0.00%, 0/32, P < 0.05). AF was induced by 25 Hz pacing in R33Q mice (48.27%, 14/29 vs. 6.25%, 2/32, P < 0.01). The mice were given 1.5 mg/kg isoproterenol (Iso), and the incidences of AF increased (65.51%, 19/29 vs. 9.21%, 3/32, P < 0.01). Electrophysiology experiments and the recording of intracellular Ca2+ indicated significant increases in the Ca2+ sparks (5.24 ± 0.75 100 μM-1.s-1 vs. 0.29 ± 0.04 100 μM-1.s-1, n = 20, P < 0.05), intracellular free Ca2+ (0.238 ± 0.009 μM vs. 0.172 ± 0.006 μM, n = 20, P < 0.05), Ca2+ wave (11.74% vs. 2.24%, n = 20, P < 0.05), transient inward current (ITi) (-0.56 ± 0.02 pA/pF vs. -0.42 ± 0.01 pA/pF, n = 10, P < 0.05), and oscillation in membrane potentials (10.71%, 3/28 vs. 4.16%, 1/24, P < 0.05) in the R33Q group, but there was no significant difference in the L-type calcium current. These effects were enhanced by Iso, and the inhibition of calmodulin-dependent protein kinase II (CaMKII) by 1 μM KN93 reversed the effects of Iso on Ca2+ sparks (5.01 ± 0.66 100 μm-1.s-1 vs. 11.33 ± 1.63 100 μm-1.s-1, P < 0.05), intracellular Ca2+ (0.245 ± 0.005 μM vs. 0.324 ± 0.008 μM, P < 0.05), Ca2+ wave (12.35% vs. 17.83%, P < 0.05), ITi (-0.61 ± 0.02 pA/pF vs. -0.78 ± 0.03 pA/pF, n = 10, P < 0.05), and oscillation in membrane potential (17.85% 5/28 vs. 32.17% 9/28, P < 0.05). The reduction of ryanodine receptor 2 (RyR2) stable subunits (Casq2, triadin, and junctin) rather than RYR2 and the increase in CaMKII, phosphor-CaMKII, phosphor-RyR2 (Ser 2814), SERCA, and NCX1.1 was reflected in the R33Q group. Conclusion: This study demonstrates that the increase in spontaneous calcium elevations corresponding to ITi that may trigger the oscillation in membrane potentials in the R33Q group, thereby increasing the risk of AF. The occurrence of spontaneous calcium elevations in R33Q atrial myocytes is due to the dysfunction of RyR2 stable subunits, CaMKII hyperactivity, and CaMKII-mediated RyR phosphorylation. An effective therapeutic strategy to intervene in Ca2+-induced AF associated with the R33Q mutation may be through CaMKII inhibition." @default.
• W2894212902 created "2018-10-05" @default.
• W2894212902 creator A5007123441 @default.
• W2894212902 creator A5008198656 @default.
• W2894212902 creator A5025183033 @default.
• W2894212902 creator A5034735922 @default.
• W2894212902 creator A5036633220 @default.
• W2894212902 creator A5040596844 @default.
• W2894212902 creator A5047733654 @default.
• W2894212902 creator A5068290128 @default.
• W2894212902 creator A5074497877 @default.
• W2894212902 creator A5083625062 @default.
• W2894212902 creator A5084743111 @default.
• W2894212902 date "2018-11-02" @default.
• W2894212902 modified "2023-10-15" @default.
• W2894212902 title "Calcium-Mediated Oscillation in Membrane Potentials and Atrial-Triggered Activity in Atrial Cells of Casq2R33Q/R33Q Mutation Mice" @default.
• W2894212902 cites W1484610284 @default.
• W2894212902 cites W1511599846 @default.
• W2894212902 cites W1583805821 @default.
• W2894212902 cites W1597890256 @default.
• W2894212902 cites W1810088673 @default.
• W2894212902 cites W1918258394 @default.
• W2894212902 cites W1968499374 @default.
• W2894212902 cites W1974540219 @default.
• W2894212902 cites W1975903898 @default.
• W2894212902 cites W1985693035 @default.
• W2894212902 cites W1999239667 @default.
• W2894212902 cites W2004324349 @default.
• W2894212902 cites W2015312438 @default.
• W2894212902 cites W2021597262 @default.
• W2894212902 cites W2040505727 @default.
• W2894212902 cites W2046701128 @default.
• W2894212902 cites W2050584392 @default.
• W2894212902 cites W2051822015 @default.
• W2894212902 cites W2058178946 @default.
• W2894212902 cites W2066089349 @default.
• W2894212902 cites W2070722888 @default.
• W2894212902 cites W2078680195 @default.
• W2894212902 cites W2093680892 @default.
• W2894212902 cites W2103036074 @default.
• W2894212902 cites W2111153312 @default.
• W2894212902 cites W2111394029 @default.
• W2894212902 cites W2121821684 @default.
• W2894212902 cites W2122162791 @default.
• W2894212902 cites W2134659769 @default.
• W2894212902 cites W2138668212 @default.
• W2894212902 cites W2144975424 @default.
• W2894212902 cites W2145384798 @default.
• W2894212902 cites W2150103532 @default.
• W2894212902 cites W2151702694 @default.
• W2894212902 cites W2168979459 @default.
• W2894212902 cites W2188449804 @default.
• W2894212902 cites W2344934244 @default.
• W2894212902 cites W2352056637 @default.
• W2894212902 cites W2754177645 @default.
• W2894212902 doi "https://doi.org/10.3389/fphys.2018.01447" @default.
• W2894212902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224359" @default.
• W2894212902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30450052" @default.
• W2894212902 hasPublicationYear "2018" @default.
• W2894212902 type Work @default.
• W2894212902 sameAs 2894212902 @default.
• W2894212902 citedByCount "9" @default.
• W2894212902 countsByYear W28942129022020 @default.
• W2894212902 countsByYear W28942129022021 @default.
• W2894212902 countsByYear W28942129022022 @default.
• W2894212902 countsByYear W28942129022023 @default.
• W2894212902 crossrefType "journal-article" @default.
• W2894212902 hasAuthorship W2894212902A5007123441 @default.
• W2894212902 hasAuthorship W2894212902A5008198656 @default.
• W2894212902 hasAuthorship W2894212902A5025183033 @default.
• W2894212902 hasAuthorship W2894212902A5034735922 @default.
• W2894212902 hasAuthorship W2894212902A5036633220 @default.
• W2894212902 hasAuthorship W2894212902A5040596844 @default.
• W2894212902 hasAuthorship W2894212902A5047733654 @default.
• W2894212902 hasAuthorship W2894212902A5068290128 @default.
• W2894212902 hasAuthorship W2894212902A5074497877 @default.
• W2894212902 hasAuthorship W2894212902A5083625062 @default.
• W2894212902 hasAuthorship W2894212902A5084743111 @default.
• W2894212902 hasBestOaLocation W28942129021 @default.
• W2894212902 hasConcept C113217602 @default.
• W2894212902 hasConcept C126322002 @default.
• W2894212902 hasConcept C134018914 @default.
• W2894212902 hasConcept C158617107 @default.
• W2894212902 hasConcept C181911157 @default.
• W2894212902 hasConcept C185263204 @default.
• W2894212902 hasConcept C185592680 @default.
• W2894212902 hasConcept C2775953344 @default.
• W2894212902 hasConcept C2779161974 @default.
• W2894212902 hasConcept C29688787 @default.
• W2894212902 hasConcept C519063684 @default.
• W2894212902 hasConcept C55493867 @default.
• W2894212902 hasConcept C71924100 @default.
• W2894212902 hasConcept C79879829 @default.
• W2894212902 hasConceptScore W2894212902C113217602 @default.
• W2894212902 hasConceptScore W2894212902C126322002 @default.
• W2894212902 hasConceptScore W2894212902C134018914 @default.
• W2894212902 hasConceptScore W2894212902C158617107 @default.
• W2894212902 hasConceptScore W2894212902C181911157 @default.
• W2894212902 hasConceptScore W2894212902C185263204 @default.
• W2894212902 hasConceptScore W2894212902C185592680 @default.

• next