FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894218928> ?p ?o ?g. }

• W2894218928 abstract "Abstract Acute myeloid leukaemia (AML) is a blood cancer affecting haematopoietic stem cells. AML is routinely treated with chemotherapy, and so it is of great interest to develop optimal chemotherapy treatment strategies. In this work, we incorporate an immune response into a stem cell model of AML, since we find that previous models lacking an immune response are inappropriate for deriving optimal control strategies. Using optimal control theory, we produce continuous controls and bang-bang controls, corresponding to a range of objectives and parameter choices. Through example calculations, we provide a practical approach to applying optimal control using Pontryagin’s Maximum Principle. In particular, we describe and explore factors that have a profound influence on numerical convergence. We find that the convergence behaviour is sensitive to the method of control updating, the nature of the control, and to the relative weighting of terms in the objective function. All codes we use to implement optimal control are made available." @default.
• W2894218928 created "2018-10-05" @default.
• W2894218928 creator A5003330950 @default.
• W2894218928 creator A5006197836 @default.
• W2894218928 creator A5048158398 @default.
• W2894218928 creator A5049102222 @default.
• W2894218928 creator A5060813398 @default.
• W2894218928 date "2018-09-28" @default.
• W2894218928 modified "2023-09-24" @default.
• W2894218928 title "Optimal control of acute myeloid leukaemia" @default.
• W2894218928 cites W1524146737 @default.
• W2894218928 cites W1982291583 @default.
• W2894218928 cites W1983641075 @default.
• W2894218928 cites W2001808786 @default.
• W2894218928 cites W2006664445 @default.
• W2894218928 cites W2018488520 @default.
• W2894218928 cites W2024150156 @default.
• W2894218928 cites W2033593383 @default.
• W2894218928 cites W2046497860 @default.
• W2894218928 cites W2058201897 @default.
• W2894218928 cites W2058390096 @default.
• W2894218928 cites W2073407522 @default.
• W2894218928 cites W2081444498 @default.
• W2894218928 cites W2092001195 @default.
• W2894218928 cites W2115842444 @default.
• W2894218928 cites W2116858301 @default.
• W2894218928 cites W2125893297 @default.
• W2894218928 cites W2142600391 @default.
• W2894218928 cites W2143758178 @default.
• W2894218928 cites W2155937296 @default.
• W2894218928 cites W2156781830 @default.
• W2894218928 cites W2162755712 @default.
• W2894218928 cites W2170846829 @default.
• W2894218928 cites W2178924775 @default.
• W2894218928 cites W2210453860 @default.
• W2894218928 cites W2290608560 @default.
• W2894218928 cites W231975775 @default.
• W2894218928 cites W2338977631 @default.
• W2894218928 cites W2344011123 @default.
• W2894218928 cites W2384094940 @default.
• W2894218928 cites W2491965793 @default.
• W2894218928 cites W2505233554 @default.
• W2894218928 cites W2526583389 @default.
• W2894218928 cites W2602373423 @default.
• W2894218928 cites W2731699938 @default.
• W2894218928 cites W2733520933 @default.
• W2894218928 cites W2738658820 @default.
• W2894218928 cites W2766352410 @default.
• W2894218928 cites W2777125604 @default.
• W2894218928 cites W2778781711 @default.
• W2894218928 cites W4234455479 @default.
• W2894218928 cites W4300831536 @default.
• W2894218928 doi "https://doi.org/10.1101/429811" @default.
• W2894218928 hasPublicationYear "2018" @default.
• W2894218928 type Work @default.
• W2894218928 sameAs 2894218928 @default.
• W2894218928 citedByCount "1" @default.
• W2894218928 countsByYear W28942189282022 @default.
• W2894218928 crossrefType "posted-content" @default.
• W2894218928 hasAuthorship W2894218928A5003330950 @default.
• W2894218928 hasAuthorship W2894218928A5006197836 @default.
• W2894218928 hasAuthorship W2894218928A5048158398 @default.
• W2894218928 hasAuthorship W2894218928A5049102222 @default.
• W2894218928 hasAuthorship W2894218928A5060813398 @default.
• W2894218928 hasBestOaLocation W28942189281 @default.
• W2894218928 hasConcept C109159458 @default.
• W2894218928 hasConcept C126255220 @default.
• W2894218928 hasConcept C126322002 @default.
• W2894218928 hasConcept C126838900 @default.
• W2894218928 hasConcept C141803461 @default.
• W2894218928 hasConcept C154945302 @default.
• W2894218928 hasConcept C162324750 @default.
• W2894218928 hasConcept C183115368 @default.
• W2894218928 hasConcept C203014093 @default.
• W2894218928 hasConcept C2775924081 @default.
• W2894218928 hasConcept C2776694085 @default.
• W2894218928 hasConcept C2777303404 @default.
• W2894218928 hasConcept C2779282312 @default.
• W2894218928 hasConcept C28328180 @default.
• W2894218928 hasConcept C2993296363 @default.
• W2894218928 hasConcept C31010330 @default.
• W2894218928 hasConcept C33923547 @default.
• W2894218928 hasConcept C41008148 @default.
• W2894218928 hasConcept C47446073 @default.
• W2894218928 hasConcept C50522688 @default.
• W2894218928 hasConcept C54355233 @default.
• W2894218928 hasConcept C71924100 @default.
• W2894218928 hasConcept C86803240 @default.
• W2894218928 hasConcept C8891405 @default.
• W2894218928 hasConcept C91575142 @default.
• W2894218928 hasConceptScore W2894218928C109159458 @default.
• W2894218928 hasConceptScore W2894218928C126255220 @default.
• W2894218928 hasConceptScore W2894218928C126322002 @default.
• W2894218928 hasConceptScore W2894218928C126838900 @default.
• W2894218928 hasConceptScore W2894218928C141803461 @default.
• W2894218928 hasConceptScore W2894218928C154945302 @default.
• W2894218928 hasConceptScore W2894218928C162324750 @default.
• W2894218928 hasConceptScore W2894218928C183115368 @default.
• W2894218928 hasConceptScore W2894218928C203014093 @default.
• W2894218928 hasConceptScore W2894218928C2775924081 @default.

• next