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- W2894221359 abstract "Direct functionalization of CH bond is rapidly becoming an indispensible tool in chemical synthesis. However, due to the ubiquity of CH bonds, achieving site-selective functionalization remains an arduous task, especially on advanced synthetic intermediates or natural products. In contrast, Nature has evolved a multitude of enzymes capable of performing this task with extraordinary selectivity, and the use of these enzymes in organic synthesis may provide a viable solution to contemporary challenges in site-selective functionalization of complex molecules. This review covers recent applications of enzymatic CH functionalization strategies in natural product synthesis, both in the context of key building block preparation and late-stage functionalization of advanced synthetic intermediates." @default.
- W2894221359 created "2018-10-05" @default.
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- W2894221359 date "2019-04-01" @default.
- W2894221359 modified "2023-10-16" @default.
- W2894221359 title "Enzymatic C H functionalizations for natural product synthesis" @default.
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- W2894221359 doi "https://doi.org/10.1016/j.cbpa.2018.09.004" @default.
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