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- W2894224653 abstract "Abstract Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N -methyl- d -aspartate receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons. Here, we demonstrate that differences in NMDAR subunit composition do not underlie this selective potentiation. Rather, a higher ambient glutamate level in the synaptic cleft of excitatory synapses on inhibitory neurons is a key factor. We show that increasing expression of glutamate transporter 1 (GLT-1) eliminates GNE-8324 potentiation in inhibitory neurons, while decreasing GLT-1 activity enables potentiation in excitatory neurons. Our results reveal an unsuspected difference between excitatory synapses onto different neuronal types, and a more prominent activation of synaptic NMDARs by ambient glutamate in inhibitory than excitatory neurons. This difference has implications for tonic NMDAR activity/signaling and the selective modulation of inhibitory neuron activity to treat brain disorders." @default.
- W2894224653 created "2018-10-05" @default.
- W2894224653 creator A5000187432 @default.
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- W2894224653 date "2018-10-01" @default.
- W2894224653 modified "2023-09-25" @default.
- W2894224653 title "Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity" @default.
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- W2894224653 cites W1613369435 @default.
- W2894224653 cites W1656913045 @default.
- W2894224653 cites W1872072116 @default.
- W2894224653 cites W1969713114 @default.
- W2894224653 cites W1970789949 @default.
- W2894224653 cites W1974916659 @default.
- W2894224653 cites W1975888261 @default.
- W2894224653 cites W1979283544 @default.
- W2894224653 cites W1983068587 @default.
- W2894224653 cites W1983245247 @default.
- W2894224653 cites W1984965974 @default.
- W2894224653 cites W1989539506 @default.
- W2894224653 cites W1994565921 @default.
- W2894224653 cites W1994664430 @default.
- W2894224653 cites W2003059369 @default.
- W2894224653 cites W2003701228 @default.
- W2894224653 cites W2007219297 @default.
- W2894224653 cites W2012850137 @default.
- W2894224653 cites W2016575029 @default.
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- W2894224653 cites W2022809683 @default.
- W2894224653 cites W2024380057 @default.
- W2894224653 cites W2025698938 @default.
- W2894224653 cites W2028279469 @default.
- W2894224653 cites W2030352252 @default.
- W2894224653 cites W2034660262 @default.
- W2894224653 cites W2036493334 @default.
- W2894224653 cites W2036495604 @default.
- W2894224653 cites W2036796078 @default.
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- W2894224653 cites W2038772185 @default.
- W2894224653 cites W2065169750 @default.
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- W2894224653 cites W2075603142 @default.
- W2894224653 cites W2078366491 @default.
- W2894224653 cites W2080811912 @default.
- W2894224653 cites W2082352870 @default.
- W2894224653 cites W2083204774 @default.
- W2894224653 cites W2084072056 @default.
- W2894224653 cites W2087105450 @default.
- W2894224653 cites W2089912569 @default.
- W2894224653 cites W2092664585 @default.
- W2894224653 cites W2093660899 @default.
- W2894224653 cites W2095780210 @default.
- W2894224653 cites W2108696245 @default.
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- W2894224653 cites W2112492148 @default.
- W2894224653 cites W2114745427 @default.
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- W2894224653 cites W2126033464 @default.
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- W2894224653 cites W2155760865 @default.
- W2894224653 cites W2157853053 @default.
- W2894224653 cites W2160644313 @default.
- W2894224653 cites W2170248994 @default.
- W2894224653 cites W2231058499 @default.
- W2894224653 cites W2260891265 @default.
- W2894224653 cites W2418457293 @default.
- W2894224653 cites W2486908111 @default.
- W2894224653 cites W2503929286 @default.
- W2894224653 cites W2548997185 @default.
- W2894224653 cites W2565750658 @default.
- W2894224653 cites W2585894066 @default.
- W2894224653 cites W2598220340 @default.
- W2894224653 cites W2734387386 @default.
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- W2894224653 doi "https://doi.org/10.1038/s41467-018-06512-7" @default.
- W2894224653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167324" @default.
- W2894224653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275542" @default.
- W2894224653 hasPublicationYear "2018" @default.
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