Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894231856> ?p ?o ?g. }
- W2894231856 endingPage "233" @default.
- W2894231856 startingPage "221" @default.
- W2894231856 abstract "Perturbations in iron homeostasis and iron accumulation feature in several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). Proteins such as α-synuclein, tau and amyloid precursor protein that are pathologically associated with neurodegeneration are involved in molecular crosstalk with iron homeostatic proteins. Quantitative susceptibility mapping, an MRI based non-invasive technique, offers proximal evaluations of iron load in regions of the brain and powerfully predicts cognitive decline. Further, small molecules that target elevated iron have shown promise against PD and AD in preclinical studies and clinical trials. Despite these strong links between altered iron homeostasis and neurodegeneration the molecular biology to describe the association between enhanced iron levels and neuron death, synaptic impairment and cognitive decline is ill defined. In this review we discuss the current understanding of brain iron homeostasis and how it may be perturbed under pathological conditions. Further, we explore the ramifications of a novel cell death pathway called ferroptosis that has provided a fresh impetus to the metal hypothesis of neurodegeneration. While lipid peroxidation plays a central role in the execution of this cell death modality the removal of iron through chelation or genetic modifications appears to extinguish the ferroptotic pathway. Conversely, tissues that harbour elevated iron may be predisposed to ferroptotic damage. These emerging findings are of relevance to neurodegeneration where ferroptotic signalling may offer new targets to mitigate cell death and dysfunction." @default.
- W2894231856 created "2018-10-05" @default.
- W2894231856 creator A5034724202 @default.
- W2894231856 creator A5035117221 @default.
- W2894231856 creator A5038374630 @default.
- W2894231856 creator A5056517132 @default.
- W2894231856 creator A5079362824 @default.
- W2894231856 date "2019-03-01" @default.
- W2894231856 modified "2023-10-11" @default.
- W2894231856 title "Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration" @default.
- W2894231856 cites W1480875188 @default.
- W2894231856 cites W1491015580 @default.
- W2894231856 cites W1493307838 @default.
- W2894231856 cites W1500435375 @default.
- W2894231856 cites W1535350845 @default.
- W2894231856 cites W1544137195 @default.
- W2894231856 cites W1589007430 @default.
- W2894231856 cites W1594017532 @default.
- W2894231856 cites W1659080107 @default.
- W2894231856 cites W1715245971 @default.
- W2894231856 cites W1743649744 @default.
- W2894231856 cites W1879047823 @default.
- W2894231856 cites W1889306845 @default.
- W2894231856 cites W1935917166 @default.
- W2894231856 cites W1963655669 @default.
- W2894231856 cites W1965050189 @default.
- W2894231856 cites W1966777603 @default.
- W2894231856 cites W1966863236 @default.
- W2894231856 cites W1970755611 @default.
- W2894231856 cites W1974844038 @default.
- W2894231856 cites W1975617209 @default.
- W2894231856 cites W1976733080 @default.
- W2894231856 cites W1976970965 @default.
- W2894231856 cites W1977308172 @default.
- W2894231856 cites W1977360731 @default.
- W2894231856 cites W1977817124 @default.
- W2894231856 cites W1978659393 @default.
- W2894231856 cites W1980560945 @default.
- W2894231856 cites W1980965312 @default.
- W2894231856 cites W1982192002 @default.
- W2894231856 cites W1985421547 @default.
- W2894231856 cites W1985613988 @default.
- W2894231856 cites W1986129921 @default.
- W2894231856 cites W1986216002 @default.
- W2894231856 cites W1994583626 @default.
- W2894231856 cites W1994990146 @default.
- W2894231856 cites W1995186464 @default.
- W2894231856 cites W1996201704 @default.
- W2894231856 cites W1996847381 @default.
- W2894231856 cites W1997183854 @default.
- W2894231856 cites W1998198134 @default.
- W2894231856 cites W1999836898 @default.
- W2894231856 cites W2001111653 @default.
- W2894231856 cites W2001177428 @default.
- W2894231856 cites W2001764001 @default.
- W2894231856 cites W2002490399 @default.
- W2894231856 cites W2004628001 @default.
- W2894231856 cites W2005683099 @default.
- W2894231856 cites W2007544675 @default.
- W2894231856 cites W2007794772 @default.
- W2894231856 cites W2009243707 @default.
- W2894231856 cites W2010278922 @default.
- W2894231856 cites W2010605130 @default.
- W2894231856 cites W2012178932 @default.
- W2894231856 cites W2015541518 @default.
- W2894231856 cites W2018080238 @default.
- W2894231856 cites W2019035911 @default.
- W2894231856 cites W2020351832 @default.
- W2894231856 cites W2020623898 @default.
- W2894231856 cites W2021363749 @default.
- W2894231856 cites W2021460298 @default.
- W2894231856 cites W2021912535 @default.
- W2894231856 cites W2022516942 @default.
- W2894231856 cites W2022708198 @default.
- W2894231856 cites W2022993728 @default.
- W2894231856 cites W2026844934 @default.
- W2894231856 cites W2027544467 @default.
- W2894231856 cites W2030249003 @default.
- W2894231856 cites W2030582538 @default.
- W2894231856 cites W2030881626 @default.
- W2894231856 cites W2032226013 @default.
- W2894231856 cites W2032587951 @default.
- W2894231856 cites W2033802563 @default.
- W2894231856 cites W2035898183 @default.
- W2894231856 cites W2036545911 @default.
- W2894231856 cites W2039314393 @default.
- W2894231856 cites W2039403847 @default.
- W2894231856 cites W2039527584 @default.
- W2894231856 cites W2042631521 @default.
- W2894231856 cites W2043291430 @default.
- W2894231856 cites W2043340127 @default.
- W2894231856 cites W2043461502 @default.
- W2894231856 cites W2043781970 @default.
- W2894231856 cites W2044872902 @default.
- W2894231856 cites W2044986100 @default.
- W2894231856 cites W2045171661 @default.
- W2894231856 cites W2046690822 @default.
- W2894231856 cites W2049066073 @default.