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- W2894300304 endingPage "1689" @default.
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- W2894300304 abstract "Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play crucial and often opposing regulatory roles in health and in pathological conditions. n-3 and n-6 PUFA undergo biotransformation to parallel series of lipid mediators that are potent modulators of many cellular processes. A wide range of biological actions have been attributed to lipid mediators derived from n-6 PUFA, and these mediators have served as lead compounds in the development of numerous clinically approved drugs, including latanoprost (Xalatan: Pfizer), which is listed on the WHO Model List of Essential Medicines. n-3 PUFA-derived mediators have received less attention, in part because early studies suggested that n-3 PUFA act simply as competitive substrates for biotransformation enzymes and decrease the formation of n-6 PUFA-derived lipid mediators. However, more recent studies suggest that n-3 PUFA-derived mediators are biologically important in their own right. It is now emerging that many n-3 PUFA-derived lipid mediators have potent and diverse activities that are distinct from their n-6 counterparts. These findings provide new opportunities for drug discovery. Herein, we review the biosynthesis of n-3 PUFA-derived lipid mediators and highlight their biological actions that may be exploited for drug development. Lastly, we provide examples of medicinal chemistry research that has utilized n-3 PUFA-derived lipid mediators as novel lead compounds in drug design." @default.
- W2894300304 created "2018-10-05" @default.
- W2894300304 creator A5003967548 @default.
- W2894300304 creator A5048035841 @default.
- W2894300304 creator A5071497406 @default.
- W2894300304 creator A5074742233 @default.
- W2894300304 date "2020-03-27" @default.
- W2894300304 modified "2023-10-16" @default.
- W2894300304 title "Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and their Application in Drug Discovery" @default.
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