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- W2894314567 abstract "The effects of Aloe vera (AV), vitamin C (VC), alpha-tocopherol (T) andgamma-tocotrienol (E) on the activities of six tumour marker enzymes; alkalinephosphatase (ALP), glutathione-S-transferase (GST), gamma-glutamyl transferase(GGT), glutathione peroxidase (GPx), glutathione reductase (GRx) and uridyldiphosphoglucuronyl transferase (UDPGT) in rat liver carcinogenesis were studied.Liver cancer was induced by diethylnitrosamine (DEN) and 2 -acetylaminofluorene(AAF) followed by partial hepatectomy. Ninety male rats (Rattus norwegicus, 120-150g, 6-7 weeks old) were divided into 15 groups. Six groups comprised the normaland supplemented-control groups. Hepatocarcinogenesis was induced in the othernine groups. Four groups were supplemented with AV, VC, E and T respectivelyand the other 4 groups were given TNC, T/AV, ENC and E/AV respectively. Thelast group remained as the cancer-control group. Aloe vera and vitamin C were administered ad libitum at doses of 0.1 mg/Lwater and 41.7 mg/L water respectively, in both control and cancer groups. Alphatocopheroland gamma-tocotrienol were administered at a dose of 34 mglkg diet and30 mglkg diet, respectively. The rats were sacrificed by cervical dislocation after 16weeks.An increase (p<0.05) in all six tumour marker enzymes was observed in thecancer-treated group compared to the normal-control group. Aloe verasupplementation significantly (p<0.05) decreased the tumour marker enzymeactivities in cancer-induced liver compared to the cancer-control group. Gammatocotrienolexerted a better effect than alpha-tocopherol in reducing the enzymeactivities in cancer-induced liver. Vitamin C significantly (p<0.05) decreased theenzyme activities in GPx, GRx, GST and UDPGT. However, non of thesupplementations decreased the alkaline phosphatase activity in the liver cancer." @default.
- W2894314567 created "2018-10-05" @default.
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- W2894314567 date "1998-02-01" @default.
- W2894314567 modified "2023-09-23" @default.
- W2894314567 title "The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis" @default.
- W2894314567 hasPublicationYear "1998" @default.
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