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• W2894317301 endingPage "e000898" @default.
• W2894317301 startingPage "e000898" @default.
• W2894317301 abstract "The intake of omega-6 vegetable oils, particularly soybean oil, began to increase in the USA starting in the early 1900s at a time when the consumption of butter and lard was on the decline.1 This caused a more than two-fold increase in the intake of linoleic acid, the main omega-6 polyunsaturated fat found in vegetable oils, which now makes up around 8% to 10% of total energy intake in the Western world. The omega-6 fat linoleic acid should not be confused with conjugated linoleic acid found in pastured animal foods.A systematic review of studies measuring the changes in linoleic acid concentration in subcutaneous adipose tissue in the USA revealed an approximate 2.5-fold increase in linoleic acid increasing from 9.1% to 21.5% from 1959 to 2008.2 Importantly, the concentration of linoleic acid in adipose tissue is a reliable marker of intake as the half-life of linoleic acid is approximately 2 years in adipose tissue. The authors of the study also noted that the increase in adipose tissue linoleic paralleled the increase in the prevalence of diabetes, obesity and asthma.2 The amount of linoleic acid in adipose tissue, but also in platelets, is additionally positively associated with coronary artery disease (CAD), whereas long-chain omega-3 (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) levels in platelets are inversely related to CAD.3 This provides rather compelling evidence that omega-3s protect whereas omega-6 linoleic acid promotes heart disease. Importantly, the increased consumption of omega-6 polyunsaturated fat linoleic acid can reduce omega-3 in the body as it competes with the alpha-linolenic acid for metabolism to longer chain polyunsaturated fats. It has been known for decades that linoleic acid, as a percentage of total fatty acids in lipids, is reduced in patients with CAD, and this has been used as an argument to …" @default.
• W2894317301 created "2018-10-05" @default.
• W2894317301 creator A5024111381 @default.
• W2894317301 creator A5062304309 @default.
• W2894317301 date "2018-09-26" @default.
• W2894317301 modified "2023-10-11" @default.
• W2894317301 title "Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis" @default.
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• W2894317301 doi "https://doi.org/10.1136/openhrt-2018-000898" @default.
• W2894317301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196963" @default.
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• W2894317301 hasPublicationYear "2018" @default.
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