Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894329539> ?p ?o ?g. }
- W2894329539 endingPage "e12301" @default.
- W2894329539 startingPage "e12301" @default.
- W2894329539 abstract "Risk factors and underlying mechanisms for liver injury associated with amiodarone remain elusive. This study aimed to investigate the drug-related covariates for acute liver injury by amiodarone-an intriguing compound of high lipophilicity, with a long half-life and notable efficacy.The medical, pharmacy, and laboratory records of new amiodarone users admitted to the cardiac or surgical intensive care units of a medical center were examined retrospectively. A Cox regression model with time-varying dose-related variables of amiodarone was utilized to estimate the hazard ratio (HR) of amiodarone-associated liver injury while adjusting for concomitant therapy and relevant covariates.Of the 131 eligible patients among 6,572 amiodarone users (46,402 prescriptions), 6 were identified as amiodarone-associated liver injury cases. In comparison to controls (n = 125), this liver injury cohort (n = 6) had significantly higher numbers of amiodarone-interacting (2.7 ± 2.0 vs 0.9 ± 0.9 drugs, P = .02) and hepatotoxic (3.8 ± 0.8 vs 2.5 ± 1.7 drugs, P = .03) comedications. The number of comedications with amiodarone-interacting potential (HR 2.07, 95% confidence interval [CI] 1.02-4.22, P = .04) and amiodarone cumulative doses standardized by body surface area (HR 6.82, 95% CI 1.72-27.04, P = .01) were independent risk factors for liver injury associated with amiodarone.Drug-related (amiodarone cumulative dose, interacting drugs) factors were significant predictors of amiodarone-associated acute liver injury. A prudent evaluation of each medication profile is warranted to attain precision medicine at the level of patient care, especially for those treated by medications with complex physicochemical and pharmacokinetic properties, such as amiodarone." @default.
- W2894329539 created "2018-10-05" @default.
- W2894329539 creator A5013916923 @default.
- W2894329539 creator A5021923650 @default.
- W2894329539 creator A5024478371 @default.
- W2894329539 creator A5065931299 @default.
- W2894329539 date "2018-09-01" @default.
- W2894329539 modified "2023-10-17" @default.
- W2894329539 title "Comedication with interacting drugs predisposes amiodarone users in cardiac and surgical intensive care units to acute liver injury" @default.
- W2894329539 cites W1963732726 @default.
- W2894329539 cites W1964255596 @default.
- W2894329539 cites W1972308512 @default.
- W2894329539 cites W1975440270 @default.
- W2894329539 cites W1978854613 @default.
- W2894329539 cites W1979392432 @default.
- W2894329539 cites W1997121318 @default.
- W2894329539 cites W1999753126 @default.
- W2894329539 cites W2025368702 @default.
- W2894329539 cites W2025704703 @default.
- W2894329539 cites W2033880369 @default.
- W2894329539 cites W2037492539 @default.
- W2894329539 cites W2048292471 @default.
- W2894329539 cites W2056922676 @default.
- W2894329539 cites W2060427373 @default.
- W2894329539 cites W2071126330 @default.
- W2894329539 cites W2079754414 @default.
- W2894329539 cites W2096090901 @default.
- W2894329539 cites W2096640416 @default.
- W2894329539 cites W2103683880 @default.
- W2894329539 cites W2108928593 @default.
- W2894329539 cites W2117178763 @default.
- W2894329539 cites W2121394112 @default.
- W2894329539 cites W2133606841 @default.
- W2894329539 cites W2134320928 @default.
- W2894329539 cites W2134956122 @default.
- W2894329539 cites W2136439359 @default.
- W2894329539 cites W2143663999 @default.
- W2894329539 cites W2148513355 @default.
- W2894329539 cites W2165788910 @default.
- W2894329539 cites W2253542416 @default.
- W2894329539 cites W2331955367 @default.
- W2894329539 cites W2417911525 @default.
- W2894329539 cites W4213205077 @default.
- W2894329539 cites W4245708227 @default.
- W2894329539 cites W74684277 @default.
- W2894329539 doi "https://doi.org/10.1097/md.0000000000012301" @default.
- W2894329539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156051" @default.
- W2894329539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30212969" @default.
- W2894329539 hasPublicationYear "2018" @default.
- W2894329539 type Work @default.
- W2894329539 sameAs 2894329539 @default.
- W2894329539 citedByCount "4" @default.
- W2894329539 countsByYear W28943295392019 @default.
- W2894329539 countsByYear W28943295392021 @default.
- W2894329539 countsByYear W28943295392022 @default.
- W2894329539 crossrefType "journal-article" @default.
- W2894329539 hasAuthorship W2894329539A5013916923 @default.
- W2894329539 hasAuthorship W2894329539A5021923650 @default.
- W2894329539 hasAuthorship W2894329539A5024478371 @default.
- W2894329539 hasAuthorship W2894329539A5065931299 @default.
- W2894329539 hasBestOaLocation W28943295391 @default.
- W2894329539 hasConcept C126322002 @default.
- W2894329539 hasConcept C156957248 @default.
- W2894329539 hasConcept C167135981 @default.
- W2894329539 hasConcept C177713679 @default.
- W2894329539 hasConcept C207103383 @default.
- W2894329539 hasConcept C2776637226 @default.
- W2894329539 hasConcept C2778094803 @default.
- W2894329539 hasConcept C2779161974 @default.
- W2894329539 hasConcept C2779384505 @default.
- W2894329539 hasConcept C2987404301 @default.
- W2894329539 hasConcept C42219234 @default.
- W2894329539 hasConcept C44249647 @default.
- W2894329539 hasConcept C71924100 @default.
- W2894329539 hasConceptScore W2894329539C126322002 @default.
- W2894329539 hasConceptScore W2894329539C156957248 @default.
- W2894329539 hasConceptScore W2894329539C167135981 @default.
- W2894329539 hasConceptScore W2894329539C177713679 @default.
- W2894329539 hasConceptScore W2894329539C207103383 @default.
- W2894329539 hasConceptScore W2894329539C2776637226 @default.
- W2894329539 hasConceptScore W2894329539C2778094803 @default.
- W2894329539 hasConceptScore W2894329539C2779161974 @default.
- W2894329539 hasConceptScore W2894329539C2779384505 @default.
- W2894329539 hasConceptScore W2894329539C2987404301 @default.
- W2894329539 hasConceptScore W2894329539C42219234 @default.
- W2894329539 hasConceptScore W2894329539C44249647 @default.
- W2894329539 hasConceptScore W2894329539C71924100 @default.
- W2894329539 hasIssue "37" @default.
- W2894329539 hasLocation W28943295391 @default.
- W2894329539 hasLocation W28943295392 @default.
- W2894329539 hasLocation W28943295393 @default.
- W2894329539 hasLocation W28943295394 @default.
- W2894329539 hasLocation W28943295395 @default.
- W2894329539 hasOpenAccess W2894329539 @default.
- W2894329539 hasPrimaryLocation W28943295391 @default.
- W2894329539 hasRelatedWork W2022392719 @default.
- W2894329539 hasRelatedWork W2098395836 @default.
- W2894329539 hasRelatedWork W2148643675 @default.