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- W2894350935 abstract "Abstract Cancer-associated fibroblasts (CAFs) are generally associated with poor clinical outcome. CAFs support tumor growth in a variety of ways and can suppress antitumor immunity and response to immunotherapy. However, a precise understanding of CAF contributions to tumor growth and therapeutic response is lacking. Discrepancies in this field of study may stem from heterogeneity in the composition and function of fibroblasts in the tumor microenvironment. Furthermore, it remains unclear whether CAFs directly interact with and suppress T cells. Here, mouse and human breast tumors were used to examine stromal cells expressing fibroblast activation protein (FAP), a surface marker for CAFs. Two discrete populations of FAP+ mesenchymal cells were identified on the basis of podoplanin (PDPN) expression: a FAP+PDPN+ population of CAFs and a FAP+PDPN− population of cancer-associated pericytes (CAPs). Although both subsets expressed extracellular matrix molecules, the CAF transcriptome was enriched in genes associated with TGFβ signaling and fibrosis compared with CAPs. In addition, CAFs were enriched at the outer edge of the tumor, in close contact with T cells, whereas CAPs were localized around vessels. Finally, FAP+PDPN+ CAFs suppressed the proliferation of T cells in a nitric oxide–dependent manner, whereas FAP+PDPN− pericytes were not immunosuppressive. Collectively, these findings demonstrate that breast tumors contain multiple populations of FAP-expressing stromal cells of dichotomous function, phenotype, and location." @default.
- W2894350935 created "2018-10-05" @default.
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- W2894350935 date "2018-12-01" @default.
- W2894350935 modified "2023-10-10" @default.
- W2894350935 title "FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors" @default.
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- W2894350935 cites W1974969251 @default.
- W2894350935 cites W1977714089 @default.
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- W2894350935 cites W2159490365 @default.
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- W2894350935 cites W2163917074 @default.
- W2894350935 cites W2170866914 @default.
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- W2894350935 cites W2442704894 @default.
- W2894350935 cites W2460036490 @default.
- W2894350935 cites W2469223980 @default.
- W2894350935 cites W2512899508 @default.
- W2894350935 cites W2520136390 @default.
- W2894350935 cites W2556868315 @default.
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- W2894350935 doi "https://doi.org/10.1158/2326-6066.cir-18-0098" @default.
- W2894350935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6597261" @default.
- W2894350935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266714" @default.
- W2894350935 hasPublicationYear "2018" @default.
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