Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894384003> ?p ?o ?g. }
- W2894384003 endingPage "1164" @default.
- W2894384003 startingPage "1157" @default.
- W2894384003 abstract "NKT cells are defined as T cells that recognize hydrophobic antigens presented by class I MHC-like molecules, including CD1d. Among CD1d-restricted NKT cells, type I and type II subsets have been noted. CD1d-restricted type I NKT cells are regarded as pro-inflammatory cells in general. On the contrary, accumulated evidence has demonstrated an anti-inflammatory property of CD1d-restricted type II NKT cells. In our earlier study using a rat model with vasculitis, we demonstrated the pro-inflammatory function of CD1d-restricted type II NKT cells and identified that one such cell recognized P518–532 of rat sterol carrier protein 2 (rSCP2518–532), which appeared on vascular endothelial cells presented by CD1d. Based on this evidence, we attempted to detect human CD1d-restricted type II NKT cells in peripheral blood using hSCP2518–532, the human counterpart of rSCP2518–532, together with a CD1d tetramer in flow cytometry. First, we determined the binding of hSCP2518–532 to CD1d. Next, we detected CD3-positive hSCP2518–532-loaded CD1d (hSCP2518–532/CD1d) tetramer-binding cells in peripheral blood of healthy donors. The abundance of TGF-β-producing cells rather than TNF-α-producing cells in CD3-positive hSCP2518–532/CD1d tetramer-binding cells suggests the anti-inflammatory property of SCP2-loaded CD1d (SCP2/CD1d) tetramer-binding type II NKT cells in healthy individuals. Furthermore, we compared cytokine profile between healthy individuals and patients with vasculitis in a pilot study. Interestingly, the percentage of TGF-β-producing cells in SCP2/CD1d tetramer-binding type II NKT cells in vasculitic patients was significantly lower than that in healthy controls despite the greater number of these cells. Although further studies to clarify the mechanism and significance of this phenomenon are needed, SCP2/CD1d tetramer-binding type II NKT cells in peripheral blood should be examined in more detail to understand the pathophysiology of vasculitides in humans. © 2018 International Society for Advancement of Cytometry" @default.
- W2894384003 created "2018-10-05" @default.
- W2894384003 creator A5004286098 @default.
- W2894384003 creator A5005720030 @default.
- W2894384003 creator A5007378624 @default.
- W2894384003 creator A5013294028 @default.
- W2894384003 creator A5029269403 @default.
- W2894384003 creator A5043880647 @default.
- W2894384003 creator A5050117829 @default.
- W2894384003 creator A5056328338 @default.
- W2894384003 creator A5059270249 @default.
- W2894384003 creator A5070052494 @default.
- W2894384003 creator A5078153316 @default.
- W2894384003 creator A5078686712 @default.
- W2894384003 creator A5079071350 @default.
- W2894384003 creator A5086647637 @default.
- W2894384003 date "2018-09-25" @default.
- W2894384003 modified "2023-10-10" @default.
- W2894384003 title "Detection of Autoreactive Type II NKT Cells: A Pilot Study of Comparison Between Healthy Individuals and Patients with Vasculitis" @default.
- W2894384003 cites W1499148988 @default.
- W2894384003 cites W1538172952 @default.
- W2894384003 cites W1555216829 @default.
- W2894384003 cites W1904333788 @default.
- W2894384003 cites W1969201936 @default.
- W2894384003 cites W1981916745 @default.
- W2894384003 cites W2013089842 @default.
- W2894384003 cites W2024192918 @default.
- W2894384003 cites W2050544484 @default.
- W2894384003 cites W2050925766 @default.
- W2894384003 cites W2064570435 @default.
- W2894384003 cites W2087287657 @default.
- W2894384003 cites W2090580631 @default.
- W2894384003 cites W2098405100 @default.
- W2894384003 cites W2100495456 @default.
- W2894384003 cites W2133403523 @default.
- W2894384003 cites W2138209968 @default.
- W2894384003 cites W2144765839 @default.
- W2894384003 cites W2161307276 @default.
- W2894384003 cites W2172217058 @default.
- W2894384003 cites W2382636977 @default.
- W2894384003 cites W2549835656 @default.
- W2894384003 cites W2791575763 @default.
- W2894384003 cites W861789265 @default.
- W2894384003 doi "https://doi.org/10.1002/cyto.a.23618" @default.
- W2894384003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30253046" @default.
- W2894384003 hasPublicationYear "2018" @default.
- W2894384003 type Work @default.
- W2894384003 sameAs 2894384003 @default.
- W2894384003 citedByCount "3" @default.
- W2894384003 countsByYear W28943840032022 @default.
- W2894384003 countsByYear W28943840032023 @default.
- W2894384003 crossrefType "journal-article" @default.
- W2894384003 hasAuthorship W2894384003A5004286098 @default.
- W2894384003 hasAuthorship W2894384003A5005720030 @default.
- W2894384003 hasAuthorship W2894384003A5007378624 @default.
- W2894384003 hasAuthorship W2894384003A5013294028 @default.
- W2894384003 hasAuthorship W2894384003A5029269403 @default.
- W2894384003 hasAuthorship W2894384003A5043880647 @default.
- W2894384003 hasAuthorship W2894384003A5050117829 @default.
- W2894384003 hasAuthorship W2894384003A5056328338 @default.
- W2894384003 hasAuthorship W2894384003A5059270249 @default.
- W2894384003 hasAuthorship W2894384003A5070052494 @default.
- W2894384003 hasAuthorship W2894384003A5078153316 @default.
- W2894384003 hasAuthorship W2894384003A5078686712 @default.
- W2894384003 hasAuthorship W2894384003A5079071350 @default.
- W2894384003 hasAuthorship W2894384003A5086647637 @default.
- W2894384003 hasBestOaLocation W28943840031 @default.
- W2894384003 hasConcept C139563560 @default.
- W2894384003 hasConcept C153911025 @default.
- W2894384003 hasConcept C203014093 @default.
- W2894384003 hasConcept C2776090121 @default.
- W2894384003 hasConcept C2778607024 @default.
- W2894384003 hasConcept C37386791 @default.
- W2894384003 hasConcept C86803240 @default.
- W2894384003 hasConcept C8891405 @default.
- W2894384003 hasConcept C95444343 @default.
- W2894384003 hasConceptScore W2894384003C139563560 @default.
- W2894384003 hasConceptScore W2894384003C153911025 @default.
- W2894384003 hasConceptScore W2894384003C203014093 @default.
- W2894384003 hasConceptScore W2894384003C2776090121 @default.
- W2894384003 hasConceptScore W2894384003C2778607024 @default.
- W2894384003 hasConceptScore W2894384003C37386791 @default.
- W2894384003 hasConceptScore W2894384003C86803240 @default.
- W2894384003 hasConceptScore W2894384003C8891405 @default.
- W2894384003 hasConceptScore W2894384003C95444343 @default.
- W2894384003 hasIssue "11" @default.
- W2894384003 hasLocation W28943840031 @default.
- W2894384003 hasLocation W28943840032 @default.
- W2894384003 hasLocation W28943840033 @default.
- W2894384003 hasOpenAccess W2894384003 @default.
- W2894384003 hasPrimaryLocation W28943840031 @default.
- W2894384003 hasRelatedWork W1756368436 @default.
- W2894384003 hasRelatedWork W2009283555 @default.
- W2894384003 hasRelatedWork W2044452623 @default.
- W2894384003 hasRelatedWork W2095967285 @default.
- W2894384003 hasRelatedWork W2103768147 @default.
- W2894384003 hasRelatedWork W2148993694 @default.
- W2894384003 hasRelatedWork W2156654829 @default.