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• W2894393413 abstract "International Task Force (ITF) guidelines established a grading scheme to support treatment of dry eye disease based on clinical signs and symptoms. The purpose of this study was to assess the impact of dry eye on vision-related function across ITF severity levels using the Ocular Surface Disease Index (OSDI) questionnaire. Non-interventional, cross-sectional study of prescription treatment-naïve dry eye patients seeking symptom relief at 10 ophthalmology and optometry practices. Clinicians assessed corneal and conjunctival staining, tear break-up time, Schirmer’s test (type I with anesthesia), and best-corrected visual acuity. Patients completed the OSDI questionnaire and OSDI overall and domain (Symptoms, Visual Function, and Environmental Triggers) scores were compared across ITF guidelines severity levels (1–4). Of 158 patients (mean age, 55 years) enrolled, 52 (33%) were ITF level 1, 54 (34%) ITF level 2, and 52 (33%) ITF levels 3/4 combined. No significant differences were observed in most baseline characteristics. Overall OSDI scores (mean [standard deviation]) were 26.5 [20.0] for ITF level 1, 33.8 [17.5] for ITF level 2, and 44.9 [26.1] for ITF level 3/4 cohorts (P < 0.0001). Component OSDI Symptoms, Visual Function, and Environmental Triggers domain scores all worsened with increasing ITF severity level (P ≤ 0.01). Dry eye disease has significant deleterious impact on vision-related function across all ITF severity levels." @default.
• W2894393413 created "2018-10-05" @default.
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• W2894393413 date "2018-09-29" @default.
• W2894393413 modified "2023-10-16" @default.
• W2894393413 title "Dry eye symptoms and impact on vision-related function across International Task Force guidelines severity levels in the United States" @default.
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• W2894393413 doi "https://doi.org/10.1186/s12886-018-0919-7" @default.
• W2894393413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162873" @default.
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• W2894393413 hasPublicationYear "2018" @default.
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