Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894408554> ?p ?o ?g. }
- W2894408554 endingPage "16" @default.
- W2894408554 startingPage "6" @default.
- W2894408554 abstract "Urease is a bacterial enzyme that is responsible for virulence of various pathogenic bacteria such as Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumoniae, Ureaplasma urealyticum, Helicobacter pylori and Mycobacterium tuberculosis. Increased urease activity aids in survival and colonization of pathogenic bacteria causing several disorders especially gastric ulceration. Hence, urease inhibitors are used for treatment of such diseases. In search of new molecules with better urease inhibitory activity, herein we report a series of acridine derived (thio)semicarbazones (4a-4e, 6a-6l) that were found to be active against urease enzyme. Molecular docking studies were carried out to better comprehend the preferential mode of binding of these compounds against urease enzyme. Docking against urease from pathogenic bacterium S. pasteurii was also carried out with favorable results. In silico ADME evaluation was done to determine drug likeness of synthesized compounds." @default.
- W2894408554 created "2018-10-05" @default.
- W2894408554 creator A5010965377 @default.
- W2894408554 creator A5022831237 @default.
- W2894408554 creator A5026094168 @default.
- W2894408554 creator A5037785485 @default.
- W2894408554 creator A5038810002 @default.
- W2894408554 creator A5040303133 @default.
- W2894408554 creator A5050202051 @default.
- W2894408554 creator A5087959158 @default.
- W2894408554 date "2019-02-01" @default.
- W2894408554 modified "2023-10-12" @default.
- W2894408554 title "Acridine-based (thio)semicarbazones and hydrazones: Synthesis, in vitro urease inhibition, molecular docking and in-silico ADME evaluation" @default.
- W2894408554 cites W1769750353 @default.
- W2894408554 cites W1831228263 @default.
- W2894408554 cites W1969550890 @default.
- W2894408554 cites W1971849220 @default.
- W2894408554 cites W1989209531 @default.
- W2894408554 cites W1996273492 @default.
- W2894408554 cites W2007785330 @default.
- W2894408554 cites W2008703092 @default.
- W2894408554 cites W2008738984 @default.
- W2894408554 cites W2032755732 @default.
- W2894408554 cites W2035410960 @default.
- W2894408554 cites W2044656382 @default.
- W2894408554 cites W2062490036 @default.
- W2894408554 cites W2109987434 @default.
- W2894408554 cites W2114853065 @default.
- W2894408554 cites W2116531314 @default.
- W2894408554 cites W2125318487 @default.
- W2894408554 cites W2132629607 @default.
- W2894408554 cites W2138094133 @default.
- W2894408554 cites W2140683510 @default.
- W2894408554 cites W2157811231 @default.
- W2894408554 cites W2218981799 @default.
- W2894408554 cites W2290738321 @default.
- W2894408554 cites W2315546268 @default.
- W2894408554 cites W2317946202 @default.
- W2894408554 cites W2487413991 @default.
- W2894408554 cites W2510927590 @default.
- W2894408554 cites W2539482149 @default.
- W2894408554 cites W2799280244 @default.
- W2894408554 cites W2810807719 @default.
- W2894408554 cites W2953312796 @default.
- W2894408554 cites W856184570 @default.
- W2894408554 doi "https://doi.org/10.1016/j.bioorg.2018.09.032" @default.
- W2894408554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267972" @default.
- W2894408554 hasPublicationYear "2019" @default.
- W2894408554 type Work @default.
- W2894408554 sameAs 2894408554 @default.
- W2894408554 citedByCount "15" @default.
- W2894408554 countsByYear W28944085542019 @default.
- W2894408554 countsByYear W28944085542020 @default.
- W2894408554 countsByYear W28944085542021 @default.
- W2894408554 countsByYear W28944085542022 @default.
- W2894408554 countsByYear W28944085542023 @default.
- W2894408554 crossrefType "journal-article" @default.
- W2894408554 hasAuthorship W2894408554A5010965377 @default.
- W2894408554 hasAuthorship W2894408554A5022831237 @default.
- W2894408554 hasAuthorship W2894408554A5026094168 @default.
- W2894408554 hasAuthorship W2894408554A5037785485 @default.
- W2894408554 hasAuthorship W2894408554A5038810002 @default.
- W2894408554 hasAuthorship W2894408554A5040303133 @default.
- W2894408554 hasAuthorship W2894408554A5050202051 @default.
- W2894408554 hasAuthorship W2894408554A5087959158 @default.
- W2894408554 hasConcept C104317684 @default.
- W2894408554 hasConcept C159110408 @default.
- W2894408554 hasConcept C181199279 @default.
- W2894408554 hasConcept C185592680 @default.
- W2894408554 hasConcept C2775905019 @default.
- W2894408554 hasConcept C2776409635 @default.
- W2894408554 hasConcept C2778883795 @default.
- W2894408554 hasConcept C2779521917 @default.
- W2894408554 hasConcept C41685203 @default.
- W2894408554 hasConcept C523546767 @default.
- W2894408554 hasConcept C54355233 @default.
- W2894408554 hasConcept C55493867 @default.
- W2894408554 hasConcept C71924100 @default.
- W2894408554 hasConcept C86803240 @default.
- W2894408554 hasConcept C89423630 @default.
- W2894408554 hasConceptScore W2894408554C104317684 @default.
- W2894408554 hasConceptScore W2894408554C159110408 @default.
- W2894408554 hasConceptScore W2894408554C181199279 @default.
- W2894408554 hasConceptScore W2894408554C185592680 @default.
- W2894408554 hasConceptScore W2894408554C2775905019 @default.
- W2894408554 hasConceptScore W2894408554C2776409635 @default.
- W2894408554 hasConceptScore W2894408554C2778883795 @default.
- W2894408554 hasConceptScore W2894408554C2779521917 @default.
- W2894408554 hasConceptScore W2894408554C41685203 @default.
- W2894408554 hasConceptScore W2894408554C523546767 @default.
- W2894408554 hasConceptScore W2894408554C54355233 @default.
- W2894408554 hasConceptScore W2894408554C55493867 @default.
- W2894408554 hasConceptScore W2894408554C71924100 @default.
- W2894408554 hasConceptScore W2894408554C86803240 @default.
- W2894408554 hasConceptScore W2894408554C89423630 @default.
- W2894408554 hasFunder F4320322799 @default.
- W2894408554 hasLocation W28944085541 @default.
- W2894408554 hasLocation W28944085542 @default.