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- W2894415586 abstract "A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance imaging (MRI) is reported. It consists of a linear π-conjugated Zn(II) porphyrin dimer linked at each extremity to a GdDOTA-type complex. This agent has shown very promising potential for PDT applications with good singlet oxygen generation in DMSO and high linear absorption in the near-infrared (λmax = 746 nm, ε ≈ 105 M–1 cm–1). Moreover, this molecule has a propensity for two-photon excited PDT with high two-photon cross sections (∼8000 GM in 880–930 nm range), which should allow for deeper tumor treatments and higher spatial precision as compared to conventional one-photon PDT. Regarding the MRI contrast agent properties, the molecule has shown superior relaxivity (14.4 mM–1 s–1 at 40 MHz, 298 K) in comparison to clinical contrast agents and the ability to be internalized in cells, thanks to its amphiphilic character. Irradiation of HeLa cells using either one-photon (740 nm) or two-photon excitation (910 nm) has led in both cases to important cell death." @default.
- W2894415586 created "2018-10-05" @default.
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- W2894415586 date "2018-09-25" @default.
- W2894415586 modified "2023-10-06" @default.
- W2894415586 title "A Porphyrin Dimer–GdDOTA Conjugate as a Theranostic Agent for One- and Two-Photon Photodynamic Therapy and MRI" @default.
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- W2894415586 doi "https://doi.org/10.1021/acs.bioconjchem.8b00634" @default.
- W2894415586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30252449" @default.
- W2894415586 hasPublicationYear "2018" @default.
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