Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894425834> ?p ?o ?g. }
- W2894425834 endingPage "785" @default.
- W2894425834 startingPage "781" @default.
- W2894425834 abstract "Preeclampsia is the leading cause of death and morbidity worldwide for the mother and fetus during pregnancy. Preeclampsia does not only affect the mother and the baby during pregnancy, but can also have long-term effects, such as the increased risk of hypertension and cardiovascular disease on the offspring and the postpartum mother later in life. The exact cause of preeclampsia is unknown, but women with preeclampsia have elevated concentrations of agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AA). These AT1-AA's through multiple studies have shown to play a significant role in the pathology and possible genesis of preeclampsia. This review will discuss the discovery of AT1-AAs and the role of AT1-AAs in the pathophysiology of preeclampsia. This review will also discuss future therapeutic approaches towards the AT1-AA to prevent adverse pregnancy outcomes. Furthermore, we will examine the relationship between AT1-AA induced hypertension associated with increased oxidative stress, antiangiogenic factors (such as soluble fms-related tyrosine kinase-1 (sFlt-1), endothelin-1 (ET-1), inflammation, endothelial dysfunction, and reduced renal function. Understanding the pathological role of AT1-AAs in hypertensive pregnancies is important as we search for novel therapies to manage preeclampsia." @default.
- W2894425834 created "2018-10-05" @default.
- W2894425834 creator A5013954782 @default.
- W2894425834 creator A5034019931 @default.
- W2894425834 creator A5034297004 @default.
- W2894425834 date "2018-11-27" @default.
- W2894425834 modified "2023-10-03" @default.
- W2894425834 title "The Role of Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor (AT1-AA) in Pathophysiology of Preeclampsia" @default.
- W2894425834 cites W1588700170 @default.
- W2894425834 cites W1857778961 @default.
- W2894425834 cites W1968036856 @default.
- W2894425834 cites W1968405139 @default.
- W2894425834 cites W1982038074 @default.
- W2894425834 cites W1982391253 @default.
- W2894425834 cites W1992969888 @default.
- W2894425834 cites W1997652121 @default.
- W2894425834 cites W2000476116 @default.
- W2894425834 cites W2003119407 @default.
- W2894425834 cites W2005539077 @default.
- W2894425834 cites W2015016465 @default.
- W2894425834 cites W2031287983 @default.
- W2894425834 cites W2041517672 @default.
- W2894425834 cites W2042923765 @default.
- W2894425834 cites W2045675189 @default.
- W2894425834 cites W2051213492 @default.
- W2894425834 cites W2051759187 @default.
- W2894425834 cites W2061442768 @default.
- W2894425834 cites W2064143839 @default.
- W2894425834 cites W2072350489 @default.
- W2894425834 cites W2081127196 @default.
- W2894425834 cites W2083022412 @default.
- W2894425834 cites W2089221056 @default.
- W2894425834 cites W2094595496 @default.
- W2894425834 cites W2103391147 @default.
- W2894425834 cites W2105020861 @default.
- W2894425834 cites W2106361822 @default.
- W2894425834 cites W2107405570 @default.
- W2894425834 cites W2114729657 @default.
- W2894425834 cites W2116806083 @default.
- W2894425834 cites W2119891509 @default.
- W2894425834 cites W2125314742 @default.
- W2894425834 cites W2132834681 @default.
- W2894425834 cites W2143396987 @default.
- W2894425834 cites W2146371213 @default.
- W2894425834 cites W2153213544 @default.
- W2894425834 cites W2155292880 @default.
- W2894425834 cites W2155857736 @default.
- W2894425834 cites W2156835401 @default.
- W2894425834 cites W2161694484 @default.
- W2894425834 cites W2164878633 @default.
- W2894425834 cites W2290324068 @default.
- W2894425834 cites W2321700603 @default.
- W2894425834 cites W2507792628 @default.
- W2894425834 cites W2531225451 @default.
- W2894425834 cites W2767038304 @default.
- W2894425834 doi "https://doi.org/10.2174/1389201019666180925121254" @default.
- W2894425834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596412" @default.
- W2894425834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30255752" @default.
- W2894425834 hasPublicationYear "2018" @default.
- W2894425834 type Work @default.
- W2894425834 sameAs 2894425834 @default.
- W2894425834 citedByCount "46" @default.
- W2894425834 countsByYear W28944258342020 @default.
- W2894425834 countsByYear W28944258342021 @default.
- W2894425834 countsByYear W28944258342022 @default.
- W2894425834 countsByYear W28944258342023 @default.
- W2894425834 crossrefType "journal-article" @default.
- W2894425834 hasAuthorship W2894425834A5013954782 @default.
- W2894425834 hasAuthorship W2894425834A5034019931 @default.
- W2894425834 hasAuthorship W2894425834A5034297004 @default.
- W2894425834 hasBestOaLocation W28944258342 @default.
- W2894425834 hasConcept C10162356 @default.
- W2894425834 hasConcept C112672928 @default.
- W2894425834 hasConcept C123915805 @default.
- W2894425834 hasConcept C126322002 @default.
- W2894425834 hasConcept C134018914 @default.
- W2894425834 hasConcept C159654299 @default.
- W2894425834 hasConcept C163764329 @default.
- W2894425834 hasConcept C170493617 @default.
- W2894425834 hasConcept C203014093 @default.
- W2894425834 hasConcept C2777218350 @default.
- W2894425834 hasConcept C2779234561 @default.
- W2894425834 hasConcept C2780972559 @default.
- W2894425834 hasConcept C2908929049 @default.
- W2894425834 hasConcept C54355233 @default.
- W2894425834 hasConcept C71924100 @default.
- W2894425834 hasConcept C86803240 @default.
- W2894425834 hasConceptScore W2894425834C10162356 @default.
- W2894425834 hasConceptScore W2894425834C112672928 @default.
- W2894425834 hasConceptScore W2894425834C123915805 @default.
- W2894425834 hasConceptScore W2894425834C126322002 @default.
- W2894425834 hasConceptScore W2894425834C134018914 @default.
- W2894425834 hasConceptScore W2894425834C159654299 @default.
- W2894425834 hasConceptScore W2894425834C163764329 @default.
- W2894425834 hasConceptScore W2894425834C170493617 @default.
- W2894425834 hasConceptScore W2894425834C203014093 @default.
- W2894425834 hasConceptScore W2894425834C2777218350 @default.
- W2894425834 hasConceptScore W2894425834C2779234561 @default.