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- W2894427028 abstract "ABSTRACT CRISPR-mediated base editors have opened unique avenues for scar-free genome-wide mutagenesis. Here, we describe a comprehensive computational workflow called beditor that can be broadly adapted for designing guide RNA libraries with a range of CRISPR-mediated base editors, PAM recognition sequences and genomes of many species. Additionally, in order to assist users in selecting the best sets of guide RNAs for their experiments, a priori estimates, called beditor scores are calculated. These beditor scores are intended to select guide RNAs that conform to requirements for optimal base editing: the editable base falls within maximum activity window of the CRISPR-mediated base editor and produces non-confounding mutational effects with minimal predicted off-target effects. We demonstrate the utility of the software by designing guide RNAs for base-editing to create or remove thousands of clinically important human disease mutations." @default.
- W2894427028 created "2018-10-05" @default.
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- W2894427028 date "2018-09-25" @default.
- W2894427028 modified "2023-10-16" @default.
- W2894427028 title "beditor: A computational workflow for designing libraries of guide RNAs for CRISPR-mediated base editing" @default.
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- W2894427028 doi "https://doi.org/10.1101/426973" @default.
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