FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894428429> ?p ?o ?g. }

• W2894428429 abstract "Abstract Objectives Restless legs syndrome (RLS) can lead to severe clinical consequences, thus negatively impacts on patients’ overall health and quality of life. Nevertheless, the pathophysiology of RLS is still unclear, resulting in underestimate, incorrect, or ignored diagnosis and in limited management and treatment. The aim of this study was to compare the plasma proteome of RLS patients and healthy controls, in the search of diagnostic biomarkers related to the disease severity. Materials and Methods Two‐dimensional gel electrophoresis coupled with liquid chromatography‐mass spectrometry was employed to analyze plasma samples of 34 patients with primary RLS, divided into two subgroups according to the disease severity: MMS group (mild‐moderate symptoms) and HS group (severe and very severe symptoms), and 17 age‐ and sex‐matched control subjects. Sleep quality, daytime sleepiness, and the level of depression were also evaluated. Results We identified eight upregulated spots, corresponding to five unique proteins, in both RLS group vs. controls (alpha‐1B‐glycoprotein, alpha‐1‐acid glycoprotein 1, haptoglobin, complement C4‐A, and immunoglobulin kappa constant); five increased spots, consistent with three unique proteins, only in HS‐RLS (kininogen‐1, immunoglobulin heavy constant alpha 1, and immunoglobulin lambda constant 2); one downregulated spot in both patient's groups (complement C3) and another one only in HS‐RLS (alpha‐1‐antitrypsin). Conclusions The significantly different plasma proteins detected in RLS were mainly associated with inflammation, immune response, and cardiovascular disorders. Particularly, the gradual increasing in immunoglobulins could be indicative of the disease severity and evolution. Accordingly, these proteins may represent a valid set of useful biomarkers for RLS diagnosis, progression and treatment." @default.
• W2894428429 created "2018-10-05" @default.
• W2894428429 creator A5019399975 @default.
• W2894428429 creator A5041200567 @default.
• W2894428429 creator A5052757149 @default.
• W2894428429 creator A5062899092 @default.
• W2894428429 creator A5069183004 @default.
• W2894428429 creator A5069189039 @default.
• W2894428429 creator A5069328169 @default.
• W2894428429 date "2018-09-22" @default.
• W2894428429 modified "2023-10-12" @default.
• W2894428429 title "Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis" @default.
• W2894428429 cites W1870391525 @default.
• W2894428429 cites W1947310368 @default.
• W2894428429 cites W1967627452 @default.
• W2894428429 cites W1969886260 @default.
• W2894428429 cites W1987525830 @default.
• W2894428429 cites W1990679521 @default.
• W2894428429 cites W1992281723 @default.
• W2894428429 cites W1995695334 @default.
• W2894428429 cites W2001537823 @default.
• W2894428429 cites W2001577653 @default.
• W2894428429 cites W2013829288 @default.
• W2894428429 cites W2024021903 @default.
• W2894428429 cites W2028861440 @default.
• W2894428429 cites W2049657925 @default.
• W2894428429 cites W2051137654 @default.
• W2894428429 cites W2064340631 @default.
• W2894428429 cites W2072833030 @default.
• W2894428429 cites W2081239487 @default.
• W2894428429 cites W2091605545 @default.
• W2894428429 cites W2118285475 @default.
• W2894428429 cites W2125015567 @default.
• W2894428429 cites W2136648677 @default.
• W2894428429 cites W2141148134 @default.
• W2894428429 cites W2147694941 @default.
• W2894428429 cites W2151487996 @default.
• W2894428429 cites W2156281356 @default.
• W2894428429 cites W2168193025 @default.
• W2894428429 cites W2169429755 @default.
• W2894428429 cites W2171491432 @default.
• W2894428429 cites W2228259905 @default.
• W2894428429 cites W2556381808 @default.
• W2894428429 cites W2584694596 @default.
• W2894428429 cites W2606811213 @default.
• W2894428429 cites W2619198175 @default.
• W2894428429 cites W2742320652 @default.
• W2894428429 cites W2753972973 @default.
• W2894428429 cites W46101779 @default.
• W2894428429 doi "https://doi.org/10.1002/brb3.1062" @default.
• W2894428429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192389" @default.
• W2894428429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30244532" @default.
• W2894428429 hasPublicationYear "2018" @default.
• W2894428429 type Work @default.
• W2894428429 sameAs 2894428429 @default.
• W2894428429 citedByCount "14" @default.
• W2894428429 countsByYear W28944284292019 @default.
• W2894428429 countsByYear W28944284292020 @default.
• W2894428429 countsByYear W28944284292021 @default.
• W2894428429 countsByYear W28944284292022 @default.
• W2894428429 countsByYear W28944284292023 @default.
• W2894428429 crossrefType "journal-article" @default.
• W2894428429 hasAuthorship W2894428429A5019399975 @default.
• W2894428429 hasAuthorship W2894428429A5041200567 @default.
• W2894428429 hasAuthorship W2894428429A5052757149 @default.
• W2894428429 hasAuthorship W2894428429A5062899092 @default.
• W2894428429 hasAuthorship W2894428429A5069183004 @default.
• W2894428429 hasAuthorship W2894428429A5069189039 @default.
• W2894428429 hasAuthorship W2894428429A5069328169 @default.
• W2894428429 hasBestOaLocation W28944284291 @default.
• W2894428429 hasConcept C10162356 @default.
• W2894428429 hasConcept C118552586 @default.
• W2894428429 hasConcept C126322002 @default.
• W2894428429 hasConcept C141071460 @default.
• W2894428429 hasConcept C146543888 @default.
• W2894428429 hasConcept C159654299 @default.
• W2894428429 hasConcept C16568411 @default.
• W2894428429 hasConcept C203014093 @default.
• W2894428429 hasConcept C206396517 @default.
• W2894428429 hasConcept C2775944032 @default.
• W2894428429 hasConcept C2776750294 @default.
• W2894428429 hasConcept C2776914184 @default.
• W2894428429 hasConcept C2779134260 @default.
• W2894428429 hasConcept C2780898057 @default.
• W2894428429 hasConcept C49453240 @default.
• W2894428429 hasConcept C64943373 @default.
• W2894428429 hasConcept C71924100 @default.
• W2894428429 hasConcept C90924648 @default.
• W2894428429 hasConceptScore W2894428429C10162356 @default.
• W2894428429 hasConceptScore W2894428429C118552586 @default.
• W2894428429 hasConceptScore W2894428429C126322002 @default.
• W2894428429 hasConceptScore W2894428429C141071460 @default.
• W2894428429 hasConceptScore W2894428429C146543888 @default.
• W2894428429 hasConceptScore W2894428429C159654299 @default.
• W2894428429 hasConceptScore W2894428429C16568411 @default.
• W2894428429 hasConceptScore W2894428429C203014093 @default.
• W2894428429 hasConceptScore W2894428429C206396517 @default.
• W2894428429 hasConceptScore W2894428429C2775944032 @default.
• W2894428429 hasConceptScore W2894428429C2776750294 @default.
• W2894428429 hasConceptScore W2894428429C2776914184 @default.

• next