Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894430718> ?p ?o ?g. }
- W2894430718 abstract "Abstract Aberrant chromosomal translocations leading to tumorigenesis have been ascribed to the heterogeneously oncogenic functions. However, how fusion transcripts exporting remains to be declared. Here, we showed that the nuclear speckle-specific long non coding RNA MALAT1 controls chimeric mRNA export processes and regulates myeloid progenitor cell differentiation in malignant hematopoiesis. We demonstrated that MALAT1 regulates chimeric mRNAs export in an m6A-dependent manner and thus controls hematopoietic cell differentiation. Specifically, reducing MALAT1 or m6A methyltransferases and the ‘reader’ YTHDC1 result in the universal retention of distinct oncogenic gene mRNAs in nucleus. Mechanically, MALAT1 hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles during chromosomal translocations and mediates the colocalization of oncogenic fusion proteins with METTL14. MALAT1 and fusion protein complexes serve as a functional loading bridge for the interaction of chimeric mRNA and METTL14. This study demonstrated a universal mechanism of chimeric mRNA transport that involves lncRNA-fusion protein-m6A autoregulatory loop for controlling myeloid cell differentiation. Targeting the lncRNA-triggered autoregulatory loop to disrupt chimeric mRNA transport might represent a new common paradigm for treating blood malignancies." @default.
- W2894430718 created "2018-10-05" @default.
- W2894430718 creator A5001081386 @default.
- W2894430718 creator A5005036619 @default.
- W2894430718 creator A5006281710 @default.
- W2894430718 creator A5007928716 @default.
- W2894430718 creator A5035126834 @default.
- W2894430718 creator A5037463896 @default.
- W2894430718 creator A5040023144 @default.
- W2894430718 creator A5076774917 @default.
- W2894430718 creator A5076874933 @default.
- W2894430718 creator A5086368014 @default.
- W2894430718 creator A5087693085 @default.
- W2894430718 date "2018-09-25" @default.
- W2894430718 modified "2023-09-25" @default.
- W2894430718 title "Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop" @default.
- W2894430718 cites W1810761522 @default.
- W2894430718 cites W1935883651 @default.
- W2894430718 cites W1981629946 @default.
- W2894430718 cites W1983547790 @default.
- W2894430718 cites W1985057553 @default.
- W2894430718 cites W1997493439 @default.
- W2894430718 cites W2002458471 @default.
- W2894430718 cites W2007657789 @default.
- W2894430718 cites W2014064723 @default.
- W2894430718 cites W2016625616 @default.
- W2894430718 cites W2018481690 @default.
- W2894430718 cites W2022770379 @default.
- W2894430718 cites W2024839121 @default.
- W2894430718 cites W2030153511 @default.
- W2894430718 cites W2032741347 @default.
- W2894430718 cites W2034066489 @default.
- W2894430718 cites W2035522667 @default.
- W2894430718 cites W2043375872 @default.
- W2894430718 cites W2045845081 @default.
- W2894430718 cites W2058303505 @default.
- W2894430718 cites W2063083122 @default.
- W2894430718 cites W2064614845 @default.
- W2894430718 cites W2065466457 @default.
- W2894430718 cites W2068631511 @default.
- W2894430718 cites W2077994180 @default.
- W2894430718 cites W2081300509 @default.
- W2894430718 cites W2082534286 @default.
- W2894430718 cites W2082592723 @default.
- W2894430718 cites W2090977067 @default.
- W2894430718 cites W2092370188 @default.
- W2894430718 cites W2098409847 @default.
- W2894430718 cites W2105123579 @default.
- W2894430718 cites W2105740818 @default.
- W2894430718 cites W2123898323 @default.
- W2894430718 cites W2133205331 @default.
- W2894430718 cites W2147567567 @default.
- W2894430718 cites W2152120196 @default.
- W2894430718 cites W2152258603 @default.
- W2894430718 cites W2163344214 @default.
- W2894430718 cites W2165547003 @default.
- W2894430718 cites W2172205939 @default.
- W2894430718 cites W2269054226 @default.
- W2894430718 cites W2291938858 @default.
- W2894430718 cites W2320718882 @default.
- W2894430718 cites W2509465044 @default.
- W2894430718 cites W2551247775 @default.
- W2894430718 cites W2749532133 @default.
- W2894430718 cites W2752985760 @default.
- W2894430718 cites W2764301500 @default.
- W2894430718 cites W2789909579 @default.
- W2894430718 doi "https://doi.org/10.1101/426742" @default.
- W2894430718 hasPublicationYear "2018" @default.
- W2894430718 type Work @default.
- W2894430718 sameAs 2894430718 @default.
- W2894430718 citedByCount "0" @default.
- W2894430718 crossrefType "posted-content" @default.
- W2894430718 hasAuthorship W2894430718A5001081386 @default.
- W2894430718 hasAuthorship W2894430718A5005036619 @default.
- W2894430718 hasAuthorship W2894430718A5006281710 @default.
- W2894430718 hasAuthorship W2894430718A5007928716 @default.
- W2894430718 hasAuthorship W2894430718A5035126834 @default.
- W2894430718 hasAuthorship W2894430718A5037463896 @default.
- W2894430718 hasAuthorship W2894430718A5040023144 @default.
- W2894430718 hasAuthorship W2894430718A5076774917 @default.
- W2894430718 hasAuthorship W2894430718A5076874933 @default.
- W2894430718 hasAuthorship W2894430718A5086368014 @default.
- W2894430718 hasAuthorship W2894430718A5087693085 @default.
- W2894430718 hasBestOaLocation W28944307181 @default.
- W2894430718 hasConcept C104317684 @default.
- W2894430718 hasConcept C105580179 @default.
- W2894430718 hasConcept C123894998 @default.
- W2894430718 hasConcept C40767141 @default.
- W2894430718 hasConcept C54355233 @default.
- W2894430718 hasConcept C67705224 @default.
- W2894430718 hasConcept C86803240 @default.
- W2894430718 hasConcept C95444343 @default.
- W2894430718 hasConceptScore W2894430718C104317684 @default.
- W2894430718 hasConceptScore W2894430718C105580179 @default.
- W2894430718 hasConceptScore W2894430718C123894998 @default.
- W2894430718 hasConceptScore W2894430718C40767141 @default.
- W2894430718 hasConceptScore W2894430718C54355233 @default.
- W2894430718 hasConceptScore W2894430718C67705224 @default.
- W2894430718 hasConceptScore W2894430718C86803240 @default.
- W2894430718 hasConceptScore W2894430718C95444343 @default.