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- W2894437219 abstract "On the basis of current treatment guidelines, we developed and validated a medication-based chronic disease score (medCDS) and tested its association with all-cause mortality of older outpatients.Considering the most prevalent chronic diseases in the elderly German population, we compiled a list of evidence-based medicines used to treat these disorders. Based on this list, a score (medCDS) was developed to predict mortality using data of a large longitudinal cohort of older outpatients (training sample; MultiCare Cohort Study). By assessing receiver-operating characteristics (ROC) curves, the performance of medCDS was then confirmed in independent cohorts (ESTHER, KORA-Age) of community-dwelling older patients and compared with already existing medication-based scores and a score using selected anatomical-therapeutic-chemical (ATC) codes.The final medCDS score had an ROC area under the curve (AUC) of 0.73 (95% CI 0.70-0.76). In the validation cohorts, its ROC AUCs were 0.79 (0.76-0.82, KORA-Age) and 0.74 (0.71-0.78, ESTHER), which were superior to already existing medication-based scores (RxRisk, CDS) and scores based on pharmacological ATC code subgroups (ATC3) or age and sex alone (Age&Sex).A new medCDS, which is based on actual treatment standards, predicts mortality of older outpatients significantly better than already existing scores." @default.
- W2894437219 created "2018-10-05" @default.
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- W2894437219 date "2019-01-01" @default.
- W2894437219 modified "2023-10-15" @default.
- W2894437219 title "A novel superior medication-based chronic disease score predicted all-cause mortality in independent geriatric cohorts" @default.
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- W2894437219 doi "https://doi.org/10.1016/j.jclinepi.2018.09.004" @default.
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- W2894437219 hasPublicationYear "2019" @default.
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