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- W2894438596 abstract "Steroids are routinely used to treat inflammation throughout the human body. Indeed, for decades, glucocorticoids have been used to reduce inflammatory processes in retinal eye disease. Most recently, their direct protective effects on photoreceptors has been investigated, although the evidence surrounding this neuroprotection is conflicting. Alternatively, the sex steroids oestrogen and progesterone have been shown conclusively to promote photoreceptor cell survival; yet retinal administration in a clinical setting has still to commence. This review chapter collates the most up to date and relevant information to determine whether these steroid groups protect photoreceptors via similar signalling pathways. Routes of administration and mechanisms of action are detailed, to determine if lessons learnt from one group may be applied to the other. Through this comparison, we demonstrate that there is great potential in developing these steroids as neuroprotective therapies for retinal degenerative diseases." @default.
- W2894438596 created "2018-10-05" @default.
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- W2894438596 date "2018-01-01" @default.
- W2894438596 modified "2023-09-24" @default.
- W2894438596 title "CHAPTER 8. Beyond Anti-inflammation: Steroid-induced Neuroprotection in the Retina" @default.
- W2894438596 doi "https://doi.org/10.1039/9781788013666-00113" @default.
- W2894438596 hasPublicationYear "2018" @default.
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