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• W2894445846 abstract "Although various types of photothermal agents are developed for photothermal cancer therapy, relatively few photothermal agents exhibit high tumor inhibition rate under relatively mild conditions. Herein, a multifunctional Bi2 S3 -Tween 20 nanoplatform loaded with PI3K inhibitor LY294002 is designed as a novel photothermal agent for inhibitor and photothermal synergistic therapy of tumors under mild photothermal therapy conditions. The LY294002 of PI3K inhibitor, after being loaded by Bi2 S3 -Tween 20 nanodots, exhibits greatly increased drug utilization and reduced side effects on normal tissues. In vivo, Bi2 S3 -Tween 20@LY294002 upon near-infrared 808 nm laser irradiation shows potent antitumor activity under relatively mild conditions (power density: 0.6 W cm-2 ). Moreover, the mechanism studies also demonstrate that Bi2 S3 -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway. The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer." @default.
• W2894445846 created "2018-10-05" @default.
• W2894445846 creator A5013518734 @default.
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• W2894445846 date "2018-09-21" @default.
• W2894445846 modified "2023-10-15" @default.
• W2894445846 title "Bi₂S₃-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo" @default.
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• W2894445846 doi "https://doi.org/10.1002/adhm.201800830" @default.
• W2894445846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240165" @default.
• W2894445846 hasPublicationYear "2018" @default.
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