FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894448068> ?p ?o ?g. }

• W2894448068 endingPage "127" @default.
• W2894448068 startingPage "121" @default.
• W2894448068 abstract "Antimicrobial peptides are one of the most promising alternatives to antibiotics for targeting pathogens without developing resistance. In this study, pore formation in 1,2-Dimyristoyl-snglycero-3-phosphocholine (DMPC) / cholesterol liposome induced by native melittin, its two mutant variants (G1I and I17 K), and cecropin P1 was investigated by monitoring the dynamics of fluorescence dye leakage. A critical peptide concentration was required for dye leakage with the rate of leakage being dependent on peptide concentration above a critical value. A lag time was required for dye leakage for low peptide concentrations that are above the critical value, which decreased at higher peptide concentrations eventually approaching zero. Lag time was found to be in the order I17 K mutant with lower hydrophobicity and higher net charge > G1I with higher hydrophobicity > melittin > cecropin P1. Cecropin P1 exhibited the highest rate of dye leakage followed by melittin, G1I, and I17 K. Size distribution and transmission electron microscopy (TEM) of liposomes exposed to peptides of different concentrations indicated pore formation with accompanied stretching of liposomes at low peptide concentrations for both melittin and cecropin P1. At much higher concentrations, however, size distribution indicated three peaks for both peptides. In both cases, TEM images show that the middle and small peaks are shown to be due to stretched liposome and broken stretched liposome respectively. For melittin, the large peak is due to peptide aggregates as well as aggregates of liposome. For cecropin P1, however, the large peak indicates cecropin P1 aggregates with solubilized lipids thus suggesting carpet mechanism." @default.
• W2894448068 created "2018-10-05" @default.
• W2894448068 creator A5034332194 @default.
• W2894448068 creator A5037544795 @default.
• W2894448068 creator A5085181538 @default.
• W2894448068 date "2019-01-01" @default.
• W2894448068 modified "2023-10-16" @default.
• W2894448068 title "Nucleation and growth of pores in 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) / cholesterol bilayer by antimicrobial peptides melittin, its mutants and cecropin P1" @default.
• W2894448068 cites W1923665285 @default.
• W2894448068 cites W1977375188 @default.
• W2894448068 cites W1982372009 @default.
• W2894448068 cites W1984456841 @default.
• W2894448068 cites W1984679573 @default.
• W2894448068 cites W1987417938 @default.
• W2894448068 cites W1989357238 @default.
• W2894448068 cites W1989998611 @default.
• W2894448068 cites W1991473184 @default.
• W2894448068 cites W1994084613 @default.
• W2894448068 cites W2001784720 @default.
• W2894448068 cites W2013133956 @default.
• W2894448068 cites W2020755269 @default.
• W2894448068 cites W2021122013 @default.
• W2894448068 cites W2027806260 @default.
• W2894448068 cites W2038536760 @default.
• W2894448068 cites W2052071310 @default.
• W2894448068 cites W2054602599 @default.
• W2894448068 cites W2056976674 @default.
• W2894448068 cites W2059624134 @default.
• W2894448068 cites W2070632568 @default.
• W2894448068 cites W2070987817 @default.
• W2894448068 cites W2078173566 @default.
• W2894448068 cites W2080105128 @default.
• W2894448068 cites W2083081735 @default.
• W2894448068 cites W2085136523 @default.
• W2894448068 cites W2087000747 @default.
• W2894448068 cites W2088667734 @default.
• W2894448068 cites W2090574691 @default.
• W2894448068 cites W2093835098 @default.
• W2894448068 cites W2097111719 @default.
• W2894448068 cites W2117149845 @default.
• W2894448068 cites W2138226073 @default.
• W2894448068 cites W2152901732 @default.
• W2894448068 cites W2311949498 @default.
• W2894448068 cites W2518053950 @default.
• W2894448068 cites W2528358794 @default.
• W2894448068 cites W2584315626 @default.
• W2894448068 cites W2615929981 @default.
• W2894448068 cites W2620941595 @default.
• W2894448068 cites W2803005912 @default.
• W2894448068 doi "https://doi.org/10.1016/j.colsurfb.2018.09.049" @default.
• W2894448068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278360" @default.
• W2894448068 hasPublicationYear "2019" @default.
• W2894448068 type Work @default.
• W2894448068 sameAs 2894448068 @default.
• W2894448068 citedByCount "16" @default.
• W2894448068 countsByYear W28944480682020 @default.
• W2894448068 countsByYear W28944480682021 @default.
• W2894448068 countsByYear W28944480682022 @default.
• W2894448068 countsByYear W28944480682023 @default.
• W2894448068 crossrefType "journal-article" @default.
• W2894448068 hasAuthorship W2894448068A5034332194 @default.
• W2894448068 hasAuthorship W2894448068A5037544795 @default.
• W2894448068 hasAuthorship W2894448068A5085181538 @default.
• W2894448068 hasConcept C12554922 @default.
• W2894448068 hasConcept C185154212 @default.
• W2894448068 hasConcept C185592680 @default.
• W2894448068 hasConcept C192157962 @default.
• W2894448068 hasConcept C2777366737 @default.
• W2894448068 hasConcept C2778001312 @default.
• W2894448068 hasConcept C2779281246 @default.
• W2894448068 hasConcept C39944091 @default.
• W2894448068 hasConcept C41625074 @default.
• W2894448068 hasConcept C540938839 @default.
• W2894448068 hasConcept C55493867 @default.
• W2894448068 hasConcept C86803240 @default.
• W2894448068 hasConceptScore W2894448068C12554922 @default.
• W2894448068 hasConceptScore W2894448068C185154212 @default.
• W2894448068 hasConceptScore W2894448068C185592680 @default.
• W2894448068 hasConceptScore W2894448068C192157962 @default.
• W2894448068 hasConceptScore W2894448068C2777366737 @default.
• W2894448068 hasConceptScore W2894448068C2778001312 @default.
• W2894448068 hasConceptScore W2894448068C2779281246 @default.
• W2894448068 hasConceptScore W2894448068C39944091 @default.
• W2894448068 hasConceptScore W2894448068C41625074 @default.
• W2894448068 hasConceptScore W2894448068C540938839 @default.
• W2894448068 hasConceptScore W2894448068C55493867 @default.
• W2894448068 hasConceptScore W2894448068C86803240 @default.
• W2894448068 hasLocation W28944480681 @default.
• W2894448068 hasLocation W28944480682 @default.
• W2894448068 hasOpenAccess W2894448068 @default.
• W2894448068 hasPrimaryLocation W28944480681 @default.
• W2894448068 hasRelatedWork W1991473184 @default.
• W2894448068 hasRelatedWork W2039701693 @default.
• W2894448068 hasRelatedWork W2066213947 @default.
• W2894448068 hasRelatedWork W2068717425 @default.
• W2894448068 hasRelatedWork W2082948099 @default.
• W2894448068 hasRelatedWork W2086517471 @default.
• W2894448068 hasRelatedWork W2091369645 @default.

• next