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- W2894449339 abstract "Introduction: Some breast cancers harbor defects in DNA repair pathways, including BRCA1 and BRCA2 mutations, leading to a genomic instability. Compromised DNA-damage repair response is found in 11 to 42% of triple negative breast cancers, with a frequency varying according to family history and ethnicity. The oral PARP inhibitors are a promising strategy in breast cancer exploiting Homologous Deficient Recombination deficiency (HRD) by a synthetic lethal approach. Several PARP inhibitors have currently reached early phase trials with studies on going in the adjuvant, neoadjuvant and metastatic setting.Area covered: Here, we review completed and ongoing trials with PARP inhibitors as well as their mechanisms of activity and acquired resistance.Expert opinion: PARP inhibitors show promising results in breast cancer. However, several issues are raised including the identification of biomarkers to predict treatment response and strategies to counteract emerging resistance." @default.
- W2894449339 created "2018-10-05" @default.
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- W2894449339 creator A5071553983 @default.
- W2894449339 date "2018-07-03" @default.
- W2894449339 modified "2023-10-16" @default.
- W2894449339 title "Emerging PARP inhibitors for treating breast cancer" @default.
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- W2894449339 doi "https://doi.org/10.1080/14728214.2018.1527900" @default.
- W2894449339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30251552" @default.
- W2894449339 hasPublicationYear "2018" @default.
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