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• W2894450644 abstract "The latest data showed a link between mental disorders and altered immune function. Schizophrenia is a multifactorial disease with numerous changes in the immunological system. The TNF-α gene is a strong candidate for schizophrenia susceptibility. The focus of this paper were the −1031 T/C, −863 C/A, −857 C/T, −308 G/A single nucleotide polymorphisms (SNPs) of the TNF-α gene. We conducted a case-control study of 401 patients with schizophrenia and 606 healthy subjects. The connections between tested SNPs and clinical variables (PANSS, age of onset, a family history, and suicide attempts) were also examined. The presence of genotypes: the C/C at −1031 T/C; the C/C at −863 C/A; the G/G at −308 G/A in the TNF-α gene was associated with a higher risk of schizophrenia in men. The presence of A allele at −308 G/A increased a risk of schizophrenia in women. Three haplotypes were associated with a higher risk of schizophrenia in men but not women. We did not reveal any associated tested SNPs with intensity of schizophrenia symptoms. Our results indicate that in addition to −308 G/A, other promoter polymorphisms of TNF-α gene are associated with schizophrenia susceptibility depending on the sex. Tested SNPs are not associated with the psychopathology of schizophrenia." @default.
• W2894450644 created "2018-10-05" @default.
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• W2894450644 date "2018-05-01" @default.
• W2894450644 modified "2023-10-17" @default.
• W2894450644 title "Promoter Polymorphisms of TNF-α Gene as a Risk Factor for Schizophrenia" @default.
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• W2894450644 doi "https://doi.org/10.1016/j.arcmed.2018.09.007" @default.
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