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• W2894460115 abstract "Neutrophils, also known as polymorphonuclear leukocytes (PMNs), are the most numerous phagocytes in the human body and are usually the first cells to arrive at the inflammation site, as part of the innate response. Neutrophils generate reactive oxygen and nitrogen species during phagocytosis and in response to soluble agonists. This functional response, termed oxidative burst, largely contributes to host defense, but it can also result in collateral damage to host tissues, being its modulation of extreme importance for the maintenance of the organism's homeostasis. Flavonoids have been suggested as therapeutic agents to avoid such damage, as these compounds exhibit antiinflammatory activity, namely through the modulation of neutrophils’ oxidative burst. This chapter summarizes the information found in the literature about the effect of flavonoids on the neutrophils’ oxidative burst. Despite the experimental variables found among the papers, it was possible to conclude that almost all the tested flavonoids have the ability to modulate neutrophils’ oxidative burst. The catechol group in the B-ring, together with the presence of the 3-OH in the C-ring and the double bond between C2–C3, are determinant for the activity. Flavonoids may constitute an alternative antiinflammatory therapy, due to their proven ability to suppress one of the most important mechanisms engaged with the onset and progression of inflammation, the production of reactive oxygen and nitrogen species." @default.
• W2894460115 created "2018-10-05" @default.
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• W2894460115 date "2018-01-01" @default.
• W2894460115 modified "2023-10-16" @default.
• W2894460115 title "Flavonoids as Modulators of Neutrophils' Oxidative Burst: Structure-Activity Relationship" @default.
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• W2894460115 doi "https://doi.org/10.1016/b978-0-12-813006-3.00020-9" @default.
• W2894460115 hasPublicationYear "2018" @default.
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