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- W2894465284 abstract "Aim: To investigate export of Hedgehog pathway (Hh) proteins Patched1, Smoothened, Sonic hedgehog and Indian hedgehog in cervical cancer cell line (CaCx) exosomes. Methods: Exosomes were isolated and characterized by Western blotting, scanning electron microscopy and in a colorimetric assay. Nucleic acids (RNA, DNA) and protein content of exosomes were analyzed. Hh pathway proteins in exosomes were detected using Western blotting. Results: CaCx secrete bio-macromolecule (DNA, RNA and proteins) enriched exosomes. CaCx exosomes contained higher amount of RNA with respect to DNA. CaCx preferentially exported Hh proteins (Patched1, Smoothened, Sonic hedgehog, Indian hedgehog) in their exosomes. Cellular uptake assay revealed rapid internalization of CaCx exosomes in human umbilical vein endothelial cells. Conclusion: Our study showed that Hh proteins are exported in CaCx exosomes." @default.
- W2894465284 created "2018-10-05" @default.
- W2894465284 creator A5031835934 @default.
- W2894465284 creator A5060111024 @default.
- W2894465284 creator A5087055317 @default.
- W2894465284 date "2018-09-01" @default.
- W2894465284 modified "2023-09-27" @default.
- W2894465284 title "Upstream Hedgehog signaling components are exported in exosomes of cervical cancer cell lines" @default.
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- W2894465284 doi "https://doi.org/10.2217/nnm-2018-0143" @default.
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