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• W2894465511 abstract "// Hung-Yun Lin 1,2,3,4 , Yu-Tang Chin 1,2 , Ya-Jung Shih 1,2 , Yi-Ru Chen 1,2 , Matthew Leinung 5 , Kelly A. Keating 6 , Shaker A. Mousa 6 and Paul J. Davis 5,6 1 PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 2 Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan 3 Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei, Taiwan 4 TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan 5 Department of Medicine, Albany Medical College, Albany, NY, USA 6 Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA Correspondence to: Paul J. Davis, email: pdavis.ordwayst@gmail.com Keywords : L-thyroxine; PD-1/PD-L1 immune checkpoint; cancer; tetrac Received: August 25, 2018     Accepted: September 08, 2018     Published: September 25, 2018 Abstract The PD-1/PD-L1 immune checkpoint involving tumor cells and host immune defense lymphocytes is a well-studied therapeutic target in oncology. That PD-1 and PD-L1 may have additional functions within tumor cells that are independent of the checkpoint is indicated by actions of a thyroid hormone analogue, L-thyroxine (T 4 ), on these checkpoint components. Acting at a cell surface receptor on plasma membrane integrin αvβ3, T 4 stimulates intracellular accumulation of PD-L1 in cancer cells. In these thyroid hormone-treated cells, T 4 -induced PD-L1 is non-immunologically anti-apoptotic, blocking activation of p53. Several laboratories have also described accumulation of PD-1 in a variety of cancer cells, not just immune defense lymphocytes and macrophages. Preliminary observations indicate that T 4 stimulates intracellular accumulation of PD-1 in tumor cells, suggesting that, like PD-L1, PD-1 has non-immunologic roles in the setting of cancer. Where such roles are anti-apoptotic, thyroid hormone-directed cancer cell accumulation of PD-1 and PD-L1 may limit effectiveness of immunologic therapy directed at the immune checkpoint." @default.
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• W2894465511 date "2018-09-25" @default.
• W2894465511 modified "2023-10-05" @default.
• W2894465511 title "In tumor cells, thyroid hormone analogues non-immunologically regulate PD-L1 and PD-1 accumulation that is anti-apoptotic" @default.
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• W2894465511 doi "https://doi.org/10.18632/oncotarget.26143" @default.
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