Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894465676> ?p ?o ?g. }
- W2894465676 abstract "In this paper, the Sequential Collapse Model (SCM) for protein folding pathways is applied to investigate the location of the non-local contacts in the intrinsically disordered state of α-synuclein, a protein implicated in the onset and spreading of several serious neurodegenerative diseases. The model relies on the entropic cost of forming protein loops due to self-crowding effects, and the protein sequence to determine contact location and stability. It is found that the model predicts the existence of several possible non-local contacts, and the location of the non-local contacts is consistent with existing experimental evidence. The bearing of these findings on the pathogenic mechanism and its regulation is discussed." @default.
- W2894465676 created "2018-10-05" @default.
- W2894465676 creator A5019365403 @default.
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- W2894465676 date "2018-12-01" @default.
- W2894465676 modified "2023-09-26" @default.
- W2894465676 title "Predicting the location of the non-local contacts in α-synuclein" @default.
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- W2894465676 doi "https://doi.org/10.1016/j.bbapap.2018.09.006" @default.
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