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• W2894471271 abstract "Limonin is a triterpenoid in citrus seeds, which has significant biological activities. However, the metabolic profile of limonin has not been fully understood. To expound its metabolism in vivo and in vitro, the metabolites of limonin was studied by rat liver microsomes, urine, and bile. High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used for identification. Among the metabolites, the structures of M1 and M3 were confirmed by chemical synthesis and nuclear magnetic resonance spectra analysis. Our results indicated that reduction and hydrolysis were the two major pathways during limonin metabolism in vivo and in vitro. The results from this work are valuable and important for understanding the metabolic process of limonin." @default.
• W2894471271 created "2018-10-05" @default.
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• W2894471271 date "2018-09-27" @default.
• W2894471271 modified "2023-10-17" @default.
• W2894471271 title "Biotransformation and Metabolic Profile of Limonin in Rat Liver Microsomes, Bile, and Urine by High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry" @default.
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• W2894471271 doi "https://doi.org/10.1021/acs.jafc.8b02057" @default.
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• W2894471271 hasPublicationYear "2018" @default.
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