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• W2894472961 abstract "The DNA damage tolerance (DDT) pathway facilitates the bypass of the fork-blocking lesions without removing them through either translesion DNA synthesis or error-free damage bypass mechanism. The Saccharomyces cerevisiae Rad5 is a multi-functional protein involved in the error-free branch of the DDT pathway, and its protein level periodically fluctuates through the cell cycle; however, the mechanistic basis and functional importance of the Rad5 level for the cell cycle regulation remain unclear. Here, we show that Rad5 is predominantly phosphorylated on serine 130 (S130) during S/G2 phase and that this modification depends on the cyclin-dependent kinase Cdc28/CDK1. We also show that the phosphorylated Rad5 species at S130 exhibit a relatively short half-life compared with non-phosphorylated Rad5 moiety, and that the Rad5 protein is partially stabilized in phosphorylation-defective rad5 S130A cells. Importantly, the elimination of this modification results in a defective cell-cycle dependent Rad5 oscillation pattern. Together, our results demonstrate that CDK1 modulates Rad5 stability by phosphorylation during the cell cycle, suggesting a crosstalk between the phosphorylation and degradation of Rad5." @default.
• W2894472961 created "2018-10-05" @default.
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• W2894472961 date "2018-09-26" @default.
• W2894472961 modified "2023-10-16" @default.
• W2894472961 title "Cyclin-dependent kinase modulates budding yeast Rad5 stability during cell cycle" @default.
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• W2894472961 doi "https://doi.org/10.1371/journal.pone.0204680" @default.
• W2894472961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157869" @default.
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