FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894478957> ?p ?o ?g. }

• W2894478957 endingPage "3670" @default.
• W2894478957 startingPage "3657" @default.
• W2894478957 abstract "The goal of this work was to develop a label-free, comprehensive, and reproducible high-resolution liquid chromatography-mass spectrometry (LC-MS)-based untargeted lipidomic workflow using a single instrument, which could be applied to biomarker discovery in both basic and clinical studies. For this, we have (i) optimized lipid extraction and elution to enhance coverage of polar and nonpolar lipids as well as resolution of their isomers, (ii) ensured MS signal reproducibility and linearity, and (iii) developed a bioinformatic pipeline to correct remaining biases. Workflow validation is reported for 48 replicates of a single human plasma sample: 1124 reproducible LC-MS signals were extracted (median signal intensity RSD = 10%), 50% of which are redundant due to adducts, dimers, in-source fragmentation, contaminations, or positive and negative ion duplicates. From the resulting 578 unique compounds, 428 lipids were identified by MS/MS, including acyl chain composition, of which 394 had RSD < 30% inside their linear intensity range, thereby enabling robust semiquantitation. MS signal intensity spanned 4 orders of magnitude, covering 16 lipid subclasses. Finally, the power of our workflow is illustrated by a proof-of-concept study in which 100 samples from healthy human subjects were analyzed and the data set was investigated using three different statistical testing strategies in order to compare their capacity in identifying the impact of sex and age on circulating lipids." @default.
• W2894478957 created "2018-10-05" @default.
• W2894478957 creator A5014340502 @default.
• W2894478957 creator A5019692389 @default.
• W2894478957 creator A5020011946 @default.
• W2894478957 creator A5022573105 @default.
• W2894478957 creator A5034604605 @default.
• W2894478957 creator A5047673468 @default.
• W2894478957 creator A5049309607 @default.
• W2894478957 creator A5050899901 @default.
• W2894478957 creator A5060728613 @default.
• W2894478957 creator A5080467834 @default.
• W2894478957 creator A5084077311 @default.
• W2894478957 date "2018-09-26" @default.
• W2894478957 modified "2023-10-13" @default.
• W2894478957 title "Comprehensive and Reproducible Untargeted Lipidomic Workflow Using LC-QTOF Validated for Human Plasma Analysis" @default.
• W2894478957 cites W1904774318 @default.
• W2894478957 cites W1968072363 @default.
• W2894478957 cites W1968486566 @default.
• W2894478957 cites W1969064400 @default.
• W2894478957 cites W1975234868 @default.
• W2894478957 cites W1987064503 @default.
• W2894478957 cites W1993868771 @default.
• W2894478957 cites W2006571576 @default.
• W2894478957 cites W2012374994 @default.
• W2894478957 cites W2034052401 @default.
• W2894478957 cites W2035847964 @default.
• W2894478957 cites W2036867114 @default.
• W2894478957 cites W2038165631 @default.
• W2894478957 cites W2042693841 @default.
• W2894478957 cites W2045408415 @default.
• W2894478957 cites W2047337429 @default.
• W2894478957 cites W2057766095 @default.
• W2894478957 cites W2060705109 @default.
• W2894478957 cites W2076944615 @default.
• W2894478957 cites W2079059974 @default.
• W2894478957 cites W2093286842 @default.
• W2894478957 cites W2107665951 @default.
• W2894478957 cites W2116687544 @default.
• W2894478957 cites W2122075984 @default.
• W2894478957 cites W2128914123 @default.
• W2894478957 cites W2131061762 @default.
• W2894478957 cites W2141640331 @default.
• W2894478957 cites W2142931933 @default.
• W2894478957 cites W2146512944 @default.
• W2894478957 cites W2148089123 @default.
• W2894478957 cites W2152311269 @default.
• W2894478957 cites W2154159866 @default.
• W2894478957 cites W2157240187 @default.
• W2894478957 cites W2167376541 @default.
• W2894478957 cites W2168526937 @default.
• W2894478957 cites W2170417182 @default.
• W2894478957 cites W2191751786 @default.
• W2894478957 cites W2276765574 @default.
• W2894478957 cites W2326422902 @default.
• W2894478957 cites W2336662501 @default.
• W2894478957 cites W2339234249 @default.
• W2894478957 cites W2346217836 @default.
• W2894478957 cites W2420961370 @default.
• W2894478957 cites W2520222164 @default.
• W2894478957 cites W2522015218 @default.
• W2894478957 cites W2559588208 @default.
• W2894478957 cites W2563261415 @default.
• W2894478957 cites W2602548445 @default.
• W2894478957 cites W2606611361 @default.
• W2894478957 cites W2610210647 @default.
• W2894478957 cites W2618877073 @default.
• W2894478957 cites W2730090876 @default.
• W2894478957 cites W2752780351 @default.
• W2894478957 cites W2754394790 @default.
• W2894478957 cites W2764166773 @default.
• W2894478957 cites W2767195265 @default.
• W2894478957 cites W2769815973 @default.
• W2894478957 cites W2789128799 @default.
• W2894478957 cites W4244540082 @default.
• W2894478957 cites W797079988 @default.
• W2894478957 doi "https://doi.org/10.1021/acs.jproteome.8b00270" @default.
• W2894478957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6572761" @default.
• W2894478957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256116" @default.
• W2894478957 hasPublicationYear "2018" @default.
• W2894478957 type Work @default.
• W2894478957 sameAs 2894478957 @default.
• W2894478957 citedByCount "27" @default.
• W2894478957 countsByYear W28944789572019 @default.
• W2894478957 countsByYear W28944789572020 @default.
• W2894478957 countsByYear W28944789572021 @default.
• W2894478957 countsByYear W28944789572022 @default.
• W2894478957 countsByYear W28944789572023 @default.
• W2894478957 crossrefType "journal-article" @default.
• W2894478957 hasAuthorship W2894478957A5014340502 @default.
• W2894478957 hasAuthorship W2894478957A5019692389 @default.
• W2894478957 hasAuthorship W2894478957A5020011946 @default.
• W2894478957 hasAuthorship W2894478957A5022573105 @default.
• W2894478957 hasAuthorship W2894478957A5034604605 @default.
• W2894478957 hasAuthorship W2894478957A5047673468 @default.
• W2894478957 hasAuthorship W2894478957A5049309607 @default.
• W2894478957 hasAuthorship W2894478957A5050899901 @default.
• W2894478957 hasAuthorship W2894478957A5060728613 @default.

• next