FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894481128> ?p ?o ?g. }

• W2894481128 abstract "Abstract Retinal signals are transmitted to cortex via neurons in the lateral geniculate nucleus (LGN), where they are processed in burst or tonic response mode. Burst mode occurs when LGN neurons are sufficiently hyperpolarized for T-Type Ca 2+ channels to de-inactivate, allowing them to open in response to a depolarization which can trigger a high-frequency sequence of Na+-based spikes (i.e. burst). In contrast, T-type channels are inactivated during tonic mode and do not contribute to spiking. Although burst mode is commonly associated with sleep and the disruption of retinogeniculate communication, bursts can also be triggered by visual stimulation, thereby transforming the retinal signals relayed to the cortex. To determine how burst mode affects retinogeniculate communication, we made recordings from monosynaptically connected retinal ganglion cells and LGN neurons in the cat during visual stimulation. Our results reveal a robust augmentation of retinal signals within the LGN during burst mode. Specifically, retinal spikes were more effective and often triggered multiple LGN spikes during periods likely to have increased T-Type Ca 2+ activity. Consistent with the biophysical properties of T-Type Ca 2+ channels, analysis revealed that effect magnitude was correlated with the duration of the preceding thalamic interspike interval and occurred even in the absence of classically defined bursts. Importantly, the augmentation of geniculate responses to retinal input was not associated with a degradation of visual signals. Together, these results indicate a graded nature of response mode and suggest that, under certain conditions, bursts facilitate the transmission of visual information to the cortex by amplifying retinal signals. Significance The thalamus is the gateway for retinal information traveling to the cortex. The lateral geniculate nucleus (LGN), like all thalamic nuclei, has two classically defined categories of spikes—tonic and burst—that differ in their underlying cellular mechanisms. Here we compare retinogeniculate communication during burst and tonic response modes. Our results show that retinogeniculate communication is enhanced during burst mode and visually evoked thalamic bursts, thereby augmenting retinal signals transmitted to cortex. Further, our results demonstrate that the influence of burst mode on retinogeniculate communication is graded and can be measured even in the absence of classically defined thalamic bursts." @default.
• W2894481128 created "2018-10-05" @default.
• W2894481128 creator A5024271978 @default.
• W2894481128 creator A5025109929 @default.
• W2894481128 creator A5026442727 @default.
• W2894481128 creator A5041719743 @default.
• W2894481128 creator A5041991758 @default.
• W2894481128 date "2018-09-26" @default.
• W2894481128 modified "2023-09-23" @default.
• W2894481128 title "The augmentation of retinogeniculate communication during thalamic burst mode" @default.
• W2894481128 cites W1484790805 @default.
• W2894481128 cites W1522787199 @default.
• W2894481128 cites W1533320261 @default.
• W2894481128 cites W1607240981 @default.
• W2894481128 cites W1869936268 @default.
• W2894481128 cites W1871288837 @default.
• W2894481128 cites W1929757528 @default.
• W2894481128 cites W1969754060 @default.
• W2894481128 cites W1970716388 @default.
• W2894481128 cites W1972869628 @default.
• W2894481128 cites W1974540718 @default.
• W2894481128 cites W1978677882 @default.
• W2894481128 cites W1981514558 @default.
• W2894481128 cites W1997385429 @default.
• W2894481128 cites W2010506656 @default.
• W2894481128 cites W2025045656 @default.
• W2894481128 cites W2025846477 @default.
• W2894481128 cites W2029325913 @default.
• W2894481128 cites W2031903220 @default.
• W2894481128 cites W2034269620 @default.
• W2894481128 cites W2041578883 @default.
• W2894481128 cites W2044986415 @default.
• W2894481128 cites W2045558676 @default.
• W2894481128 cites W2047857929 @default.
• W2894481128 cites W2052804852 @default.
• W2894481128 cites W2064920815 @default.
• W2894481128 cites W2075394357 @default.
• W2894481128 cites W2080684720 @default.
• W2894481128 cites W2092144863 @default.
• W2894481128 cites W2101814643 @default.
• W2894481128 cites W2103754852 @default.
• W2894481128 cites W2108692322 @default.
• W2894481128 cites W2116454469 @default.
• W2894481128 cites W2120836623 @default.
• W2894481128 cites W2123713348 @default.
• W2894481128 cites W2124084477 @default.
• W2894481128 cites W2129526664 @default.
• W2894481128 cites W2145117823 @default.
• W2894481128 cites W2151643908 @default.
• W2894481128 cites W2155706938 @default.
• W2894481128 cites W2162489171 @default.
• W2894481128 cites W21633769 @default.
• W2894481128 cites W2168138935 @default.
• W2894481128 cites W2233242573 @default.
• W2894481128 cites W2270123694 @default.
• W2894481128 cites W2331450702 @default.
• W2894481128 cites W2543872624 @default.
• W2894481128 cites W2786045271 @default.
• W2894481128 cites W657607595 @default.
• W2894481128 doi "https://doi.org/10.1101/427674" @default.
• W2894481128 hasPublicationYear "2018" @default.
• W2894481128 type Work @default.
• W2894481128 sameAs 2894481128 @default.
• W2894481128 citedByCount "0" @default.
• W2894481128 crossrefType "posted-content" @default.
• W2894481128 hasAuthorship W2894481128A5024271978 @default.
• W2894481128 hasAuthorship W2894481128A5025109929 @default.
• W2894481128 hasAuthorship W2894481128A5026442727 @default.
• W2894481128 hasAuthorship W2894481128A5041719743 @default.
• W2894481128 hasAuthorship W2894481128A5041991758 @default.
• W2894481128 hasBestOaLocation W28944811281 @default.
• W2894481128 hasConcept C121332964 @default.
• W2894481128 hasConcept C12554922 @default.
• W2894481128 hasConcept C127573956 @default.
• W2894481128 hasConcept C133529732 @default.
• W2894481128 hasConcept C169760540 @default.
• W2894481128 hasConcept C195221683 @default.
• W2894481128 hasConcept C24998067 @default.
• W2894481128 hasConcept C2776362945 @default.
• W2894481128 hasConcept C2777093970 @default.
• W2894481128 hasConcept C2777452900 @default.
• W2894481128 hasConcept C2777624874 @default.
• W2894481128 hasConcept C2779246727 @default.
• W2894481128 hasConcept C2779345533 @default.
• W2894481128 hasConcept C2780723820 @default.
• W2894481128 hasConcept C2780827179 @default.
• W2894481128 hasConcept C38137364 @default.
• W2894481128 hasConcept C4141045 @default.
• W2894481128 hasConcept C55493867 @default.
• W2894481128 hasConcept C86803240 @default.
• W2894481128 hasConceptScore W2894481128C121332964 @default.
• W2894481128 hasConceptScore W2894481128C12554922 @default.
• W2894481128 hasConceptScore W2894481128C127573956 @default.
• W2894481128 hasConceptScore W2894481128C133529732 @default.
• W2894481128 hasConceptScore W2894481128C169760540 @default.
• W2894481128 hasConceptScore W2894481128C195221683 @default.
• W2894481128 hasConceptScore W2894481128C24998067 @default.
• W2894481128 hasConceptScore W2894481128C2776362945 @default.
• W2894481128 hasConceptScore W2894481128C2777093970 @default.
• W2894481128 hasConceptScore W2894481128C2777452900 @default.

• next