Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894489676> ?p ?o ?g. }
- W2894489676 endingPage "238" @default.
- W2894489676 startingPage "229" @default.
- W2894489676 abstract "Purpose: To define if exposure to tobacco smoke (TS) could induce reduction of bone mass and impairment of bone architecture, features observed in osteoporosis in normotensive rats and the influence of TS exposure on the osteoporotic features exhibited in the spontaneously hypertensive (SH) rats.Methods: Normotensive Wistar Kyoto (WKY) and SH rats were exposed to filtered air or TS for 8 weeks, then their proximal femurs were extracted for micro-computed tomography (micro-CT) assessment, histological and immune-histological examinations to quantify the adverse influence of TS exposure on the bone mass and density, as well as bone architecture.Results: We found that TS exposure not only induced significant decreases in bone mineral density (BMD), bone volume (BV), cortical and trabecular thickness (Ct.Th and Tb.Th), trabecular surface area (Tb.Ar), expression of hypoxia-inducible factor-1α (HIF-1α) in the trabecular marrow, delayed ossification of cartilage, as well as statistical increases in trabecular separation (Tb.SP) and the number of trabecular marrow adipocytes in both WKY and SH rats, but also exacerbated multiple features of osteoporosis exhibited in SH rats, including decreased BMD, Ct.Th, Tb.Ar, HIF-1α expression, delayed cartilage ossification, and increased Tb.SP.Conclusions: Our results show that TS exposure can reduce bone mass and impair bone architecture and exacerbate multiple features of osteoporosis exhibited in SH rats." @default.
- W2894489676 created "2018-10-05" @default.
- W2894489676 creator A5005701381 @default.
- W2894489676 creator A5005719758 @default.
- W2894489676 creator A5008249397 @default.
- W2894489676 creator A5012790617 @default.
- W2894489676 creator A5039982770 @default.
- W2894489676 creator A5042426397 @default.
- W2894489676 creator A5053243924 @default.
- W2894489676 creator A5058128997 @default.
- W2894489676 creator A5076065826 @default.
- W2894489676 date "2018-05-12" @default.
- W2894489676 modified "2023-10-14" @default.
- W2894489676 title "Exposure to tobacco smoke increases bone loss in spontaneously hypertensive rats" @default.
- W2894489676 cites W1484043356 @default.
- W2894489676 cites W1580329667 @default.
- W2894489676 cites W1583699618 @default.
- W2894489676 cites W1964231707 @default.
- W2894489676 cites W1964439844 @default.
- W2894489676 cites W1965335428 @default.
- W2894489676 cites W1967212422 @default.
- W2894489676 cites W1968265406 @default.
- W2894489676 cites W1970459985 @default.
- W2894489676 cites W1976943496 @default.
- W2894489676 cites W1983763042 @default.
- W2894489676 cites W1985248108 @default.
- W2894489676 cites W1987163081 @default.
- W2894489676 cites W1987371643 @default.
- W2894489676 cites W1987847633 @default.
- W2894489676 cites W1991722827 @default.
- W2894489676 cites W1991958278 @default.
- W2894489676 cites W1995064385 @default.
- W2894489676 cites W1996475346 @default.
- W2894489676 cites W1997470977 @default.
- W2894489676 cites W2003105246 @default.
- W2894489676 cites W2003377305 @default.
- W2894489676 cites W2003904705 @default.
- W2894489676 cites W2006079390 @default.
- W2894489676 cites W2014245338 @default.
- W2894489676 cites W2019022588 @default.
- W2894489676 cites W2024988321 @default.
- W2894489676 cites W2029810059 @default.
- W2894489676 cites W2031998606 @default.
- W2894489676 cites W2033432515 @default.
- W2894489676 cites W2038607522 @default.
- W2894489676 cites W2044181198 @default.
- W2894489676 cites W2047191162 @default.
- W2894489676 cites W2047511843 @default.
- W2894489676 cites W2053094047 @default.
- W2894489676 cites W2053712883 @default.
- W2894489676 cites W2053740873 @default.
- W2894489676 cites W2054635074 @default.
- W2894489676 cites W2058878434 @default.
- W2894489676 cites W2061758508 @default.
- W2894489676 cites W2063408237 @default.
- W2894489676 cites W2074121232 @default.
- W2894489676 cites W2075062032 @default.
- W2894489676 cites W2080429836 @default.
- W2894489676 cites W2082615033 @default.
- W2894489676 cites W2083422332 @default.
- W2894489676 cites W2084355267 @default.
- W2894489676 cites W2086964102 @default.
- W2894489676 cites W2094320187 @default.
- W2894489676 cites W2099397203 @default.
- W2894489676 cites W2100140007 @default.
- W2894489676 cites W2103469423 @default.
- W2894489676 cites W2105389636 @default.
- W2894489676 cites W2110867777 @default.
- W2894489676 cites W2117216486 @default.
- W2894489676 cites W2139237341 @default.
- W2894489676 cites W2141526970 @default.
- W2894489676 cites W2142262092 @default.
- W2894489676 cites W2150819809 @default.
- W2894489676 cites W2152395959 @default.
- W2894489676 cites W2154013090 @default.
- W2894489676 cites W2157242620 @default.
- W2894489676 cites W2158815446 @default.
- W2894489676 cites W2167442670 @default.
- W2894489676 cites W2269475172 @default.
- W2894489676 cites W2415201951 @default.
- W2894489676 cites W2515888990 @default.
- W2894489676 cites W4242212054 @default.
- W2894489676 doi "https://doi.org/10.1080/08958378.2018.1506838" @default.
- W2894489676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257116" @default.
- W2894489676 hasPublicationYear "2018" @default.
- W2894489676 type Work @default.
- W2894489676 sameAs 2894489676 @default.
- W2894489676 citedByCount "2" @default.
- W2894489676 countsByYear W28944896762021 @default.
- W2894489676 countsByYear W28944896762022 @default.
- W2894489676 crossrefType "journal-article" @default.
- W2894489676 hasAuthorship W2894489676A5005701381 @default.
- W2894489676 hasAuthorship W2894489676A5005719758 @default.
- W2894489676 hasAuthorship W2894489676A5008249397 @default.
- W2894489676 hasAuthorship W2894489676A5012790617 @default.
- W2894489676 hasAuthorship W2894489676A5039982770 @default.
- W2894489676 hasAuthorship W2894489676A5042426397 @default.
- W2894489676 hasAuthorship W2894489676A5053243924 @default.