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- W2894514321 abstract "Deficiencies in DNA mismatch repair (MMR) machinery result in greater incidence of DNA base pair mismatches in many types of cancer cells relative to normal cells. Consequently, luminescent probes capable of signaling the presence of mismatched DNA hold promise as potential cancer diagnostic and therapeutic tools. In this study, a series of cyclometalated platinum(II) complexes with sterically expansive tetraarylethylene ligands were synthesized and examined for selective detection of mismatched DNA. Increased steric bulk of the tetraarylethylene ligands in these complexes was observed to correlate with greater preferential luminescence enhancement in the presence of hairpin DNA oligonucleotides containing a mismatched site compared to well-matched oligonucleotides, with the most effective complex displaying ∼14-fold higher emission upon binding CC mismatched oligonucleotides compared to well-matched oligonucleotides. The results indicate binding to mismatched sites in DNA oligonucleotides occurs through metalloinsertion, and the luminescence response increases as a function of thermodynamic destabilization of the mismatch. Luminescence quenching experiments with Cu(phen)22+ and NaI further indicate mismatch binding from the minor groove, consistent with metalloinsertion. Binding to CC mismatched oligonucleotides was also investigated by isothermal titration calorimetry and UV-melting studies. These results demonstrate the efficacy of tetraarylethylene-based platinum(II) complexes for detection of mismatched DNA and establish a new molecular platform for development of organometallic DNA binding agents." @default.
- W2894514321 created "2018-10-05" @default.
- W2894514321 creator A5025346343 @default.
- W2894514321 creator A5038798358 @default.
- W2894514321 date "2018-09-27" @default.
- W2894514321 modified "2023-09-27" @default.
- W2894514321 title "Platinum(II) Complexes with Sterically Expansive Tetraarylethylene Ligands as Probes for Mismatched DNA" @default.
- W2894514321 cites W153075741 @default.
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- W2894514321 cites W1987354680 @default.
- W2894514321 cites W1987604182 @default.
- W2894514321 cites W1989180035 @default.
- W2894514321 cites W1992406775 @default.
- W2894514321 cites W1992830991 @default.
- W2894514321 cites W1993373025 @default.
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- W2894514321 cites W2006443314 @default.
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- W2894514321 cites W2013008937 @default.
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- W2894514321 cites W2022433812 @default.
- W2894514321 cites W2026950328 @default.
- W2894514321 cites W2028553114 @default.
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- W2894514321 cites W2029880387 @default.
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- W2894514321 doi "https://doi.org/10.1021/acs.inorgchem.8b01782" @default.
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- W2894514321 hasPublicationYear "2018" @default.
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