FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894524724> ?p ?o ?g. }

• W2894524724 endingPage "346" @default.
• W2894524724 startingPage "335" @default.
• W2894524724 abstract "Mechlorethamine (HN2) is an alkylating agent and sulfur mustard mimetic. Topical exposure to HN2 is associated with tissue blistering. Previous work in our laboratory has shown that ebselen (EB-1) possesses anti-vesicant, anti-inflammatory, anti-bacterial, anti-fungal, and cytoprotective properties, both in vivo and in vitro. We recently reported that ebselen oxide (EB-2), an analog of EB-1 with a tetravalent selenium atom, also possesses anti-bacterial and anti-fungal activity and confers cytoprotection against HN2 in vitro. The purpose of the present study was to determine the vesicant countermeasure potential of EB-2 using the mouse ear vesicant model (MEVM). Compared to control ears, mouse ears exposed to a single dose of HN2 (0.500 µmol/ear) showed an increase in wet weights, ear thickness, hyperplasia, vesication, and inflammatory cell infiltration after 24 h. Fluorescence microscopy of terminal deoxynucleotidyl transferase (TdT) dUTP nick end labeling (TUNEL)-stained sections showed that the occurrence of apoptosis extended from the epidermis of the HN2-treated side, all the way to the contralateral epidermis. In contrast, HN2-exposed ears treated topically with EB-2 at a test dose of 0.250 mg/ear showed a significant decrease in wet weight (12% less vs. HN2 alone), morphometric thickness (13% less vs. HN2 alone), and vesication. In addition, TUNEL staining revealed that HN2 ears treated with EB-2 (0.250 mg/ear) showed a decrease in apoptosis as compared to the HN2 group. EB-2 also reduced the abundance of matrix metalloproteinase-9 (MMP-9) in ear tissues exposed to HN2. Taken together, our study demonstrates that EB-2 is an efficacious countermeasure to HN2." @default.
• W2894524724 created "2018-10-05" @default.
• W2894524724 creator A5004943123 @default.
• W2894524724 creator A5012741413 @default.
• W2894524724 creator A5015354679 @default.
• W2894524724 creator A5060248275 @default.
• W2894524724 creator A5068233814 @default.
• W2894524724 creator A5086281597 @default.
• W2894524724 date "2018-09-26" @default.
• W2894524724 modified "2023-10-02" @default.
• W2894524724 title "Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model" @default.
• W2894524724 cites W1590592584 @default.
• W2894524724 cites W1824982923 @default.
• W2894524724 cites W1899829125 @default.
• W2894524724 cites W1970996854 @default.
• W2894524724 cites W1972268592 @default.
• W2894524724 cites W1972457282 @default.
• W2894524724 cites W1974282067 @default.
• W2894524724 cites W1979158020 @default.
• W2894524724 cites W1981945055 @default.
• W2894524724 cites W1986669241 @default.
• W2894524724 cites W1994180565 @default.
• W2894524724 cites W2000078243 @default.
• W2894524724 cites W2009345065 @default.
• W2894524724 cites W2011047657 @default.
• W2894524724 cites W2019470303 @default.
• W2894524724 cites W2020693567 @default.
• W2894524724 cites W2029729156 @default.
• W2894524724 cites W2053076897 @default.
• W2894524724 cites W2056774514 @default.
• W2894524724 cites W2060435160 @default.
• W2894524724 cites W2077965432 @default.
• W2894524724 cites W2083882252 @default.
• W2894524724 cites W2090592512 @default.
• W2894524724 cites W2090631453 @default.
• W2894524724 cites W2095455063 @default.
• W2894524724 cites W2103009905 @default.
• W2894524724 cites W2108064850 @default.
• W2894524724 cites W2113525387 @default.
• W2894524724 cites W2115696589 @default.
• W2894524724 cites W2124529895 @default.
• W2894524724 cites W2134725261 @default.
• W2894524724 cites W2136159937 @default.
• W2894524724 cites W2145372100 @default.
• W2894524724 cites W2152099551 @default.
• W2894524724 cites W2159882838 @default.
• W2894524724 cites W2387165602 @default.
• W2894524724 cites W2534316741 @default.
• W2894524724 cites W2753634282 @default.
• W2894524724 cites W2769520303 @default.
• W2894524724 cites W2792840204 @default.
• W2894524724 doi "https://doi.org/10.1080/01480545.2018.1488858" @default.
• W2894524724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257109" @default.
• W2894524724 hasPublicationYear "2018" @default.
• W2894524724 type Work @default.
• W2894524724 sameAs 2894524724 @default.
• W2894524724 citedByCount "7" @default.
• W2894524724 countsByYear W28945247242018 @default.
• W2894524724 countsByYear W28945247242020 @default.
• W2894524724 countsByYear W28945247242021 @default.
• W2894524724 countsByYear W28945247242023 @default.
• W2894524724 crossrefType "journal-article" @default.
• W2894524724 hasAuthorship W2894524724A5004943123 @default.
• W2894524724 hasAuthorship W2894524724A5012741413 @default.
• W2894524724 hasAuthorship W2894524724A5015354679 @default.
• W2894524724 hasAuthorship W2894524724A5060248275 @default.
• W2894524724 hasAuthorship W2894524724A5068233814 @default.
• W2894524724 hasAuthorship W2894524724A5086281597 @default.
• W2894524724 hasBestOaLocation W28945247242 @default.
• W2894524724 hasConcept C105702510 @default.
• W2894524724 hasConcept C109523444 @default.
• W2894524724 hasConcept C126322002 @default.
• W2894524724 hasConcept C142724271 @default.
• W2894524724 hasConcept C150903083 @default.
• W2894524724 hasConcept C153911025 @default.
• W2894524724 hasConcept C154113507 @default.
• W2894524724 hasConcept C181199279 @default.
• W2894524724 hasConcept C185592680 @default.
• W2894524724 hasConcept C190283241 @default.
• W2894524724 hasConcept C196795494 @default.
• W2894524724 hasConcept C202751555 @default.
• W2894524724 hasConcept C207001950 @default.
• W2894524724 hasConcept C2775838275 @default.
• W2894524724 hasConcept C2776458125 @default.
• W2894524724 hasConcept C2776694085 @default.
• W2894524724 hasConcept C2776755627 @default.
• W2894524724 hasConcept C2778670039 @default.
• W2894524724 hasConcept C2778760513 @default.
• W2894524724 hasConcept C2779138974 @default.
• W2894524724 hasConcept C55493867 @default.
• W2894524724 hasConcept C71924100 @default.
• W2894524724 hasConcept C86803240 @default.
• W2894524724 hasConceptScore W2894524724C105702510 @default.
• W2894524724 hasConceptScore W2894524724C109523444 @default.
• W2894524724 hasConceptScore W2894524724C126322002 @default.
• W2894524724 hasConceptScore W2894524724C142724271 @default.
• W2894524724 hasConceptScore W2894524724C150903083 @default.
• W2894524724 hasConceptScore W2894524724C153911025 @default.

• next