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• W2894525107 startingPage "1057" @default.
• W2894525107 abstract "Central nervous system (CNS) neurons typically fail to regrow their axons after injury. Injuries or neuropathies that damage CNS axons and disrupt neuronal circuitry often result in permanent functional deficits. Axon regeneration is therefore an intensely pursued therapeutic strategy for numerous CNS disorders. Phenotypic screens utilizing primary neurons have proven successful at identifying agents that promote axon regeneration in vivo. Here, we report the screening of mixture-based combinatorial small molecule libraries in a phenotypic assay utilizing primary CNS neurons and the discovery of neurite outgrowth promoters with low nanomolar potency." @default.
• W2894525107 created "2018-10-05" @default.
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• W2894525107 date "2018-09-24" @default.
• W2894525107 modified "2023-09-28" @default.
• W2894525107 title "Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency" @default.
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• W2894525107 doi "https://doi.org/10.1021/acsmedchemlett.8b00425" @default.
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