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- W2894526443 abstract "Significance Direct interactions between natural killer (NK) cells and bacteria are rarely observed, and the consequences of these interactions not well understood. We show that human NK cells exposed to the bacterium group B Streptococcus (GBS) undergo pyroptosis, a type of inflammatory cell death. By releasing inflammatory mediators, pyroptosis is thought to be a way for sentinels to die and alert the immune system of infection. Interestingly, we also found that GBS has a protein that binds to Siglec-7, an inhibitory molecule on NK cells. Siglec-7 inhibits pyroptosis and silences the sentinel activity of NK cells by preventing the release of inflammatory molecules. These studies suggest that a human pathogen can silence the sentinel by specific interaction with a Siglec protein." @default.
- W2894526443 created "2018-10-05" @default.
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- W2894526443 date "2018-09-25" @default.
- W2894526443 modified "2023-09-25" @default.
- W2894526443 title "Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells" @default.
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- W2894526443 doi "https://doi.org/10.1073/pnas.1804108115" @default.
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