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• W2894527871 startingPage "844" @default.
• W2894527871 abstract "Cutaneous leishmaniasis (CL) presents as 1 or more skin lesions, which makes local therapy inherently attractive compared to systemic therapy that exposes the whole body to a drug. For 30 years, 15% paromomycin topical formulations have been in clinical experimentation. Recently, 15% paromomycin in Aquaphilic, a complex base to facilitate adsorption into the lesion, was found superior to aquaphilic vehicle for Old World Leishmania major disease. We performed a randomized trial of 15% paromomycin in Aquaphilic (40 patients) vs Aquaphilic vehicle (20 patients) vs a positive control (intralesional pentamidine; 20 patients) against L. braziliensis CL in Bolivia Cure rates after 6 months of follow-up were 31 of 40 (77.5%, 95% confidence interval [CI] 62.5–88%) for paromomycin-Aquaphilic, 2 of 20 (10%, 95% CI 3–30%) for Aquaphilic vehicle (P < .0001 vs paromomycin-Aquaphilic), and 14 of 20 (70%, 95% CI 48–85.5%) for intralesional pentamidine. Both paromomycin-Aquaphilic and the Aquaphilic vehicle were very well tolerated, with only grade 1 adverse reactions in 5–10% of patients. Against L. braziliensis CL, a prevalent, aggressive form of New World CL, 15% paromomycin-aquaphilic was vastly superior to a negative vehicle control and was comparable in efficacy to a positive control. This study enlarges the potential use of 15% paromomycin-Aquaphilic from one form of Old World CL to CL more generally. NCT03096457." @default.
• W2894527871 created "2018-10-05" @default.
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• W2894527871 date "2018-09-27" @default.
• W2894527871 modified "2023-09-26" @default.
• W2894527871 title "Topical 15% Paromomycin-Aquaphilic for Bolivian <i>Leishmania braziliensis</i> Cutaneous Leishmaniasis: A Randomized, Placebo-controlled Trial" @default.
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• W2894527871 doi "https://doi.org/10.1093/cid/ciy619" @default.
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