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- W2894528081 abstract "In the twenty first century, the changing epidemiology of inflammatory bowel disease (IBD) globally with increasing disease incidence across many countries relates to the altered gut microbiota, due to a combinatorial effect of environmental factors, human immune responses and genetics. IBD is a gastrointestinal disease associated with dysbiosis, characterized by changes in gut microbial communities that include an expansion of facultative anaerobic bacteria of the family Enterobacteriaceae. Advances in high-throughput sequencing enable us to entangle the gut microbiota in human health and IBD beyond the bacterial microbiota, including mycobiota, virobiota and helminthes. Caudovirales (viruses) and Basidiomycota, Ascomycota and C.albicans (fungi) are revealed to be increased in IBD. The deconvolution of the gut microbiota in IBD lays the basis for unveiling the roles of these various gut microbiota components in IBD pathogenesis and being conductive to instructing on future IBD diagnosis and therapeutics. Here we comprehensively elucidate the alterations in the gut microbiota in IBD, discuss the effect of diets in the gut microbiota in relation to IBD, and illustrate the potential of manipulation of gut microbiota for IBD therapeutics. The therapeutic strategy of antibiotics, probiotics, prebiotics and fecal microbiota transplantation will benefit the effective application of precision microbiome manipulation in IBD." @default.
- W2894528081 created "2018-10-05" @default.
- W2894528081 creator A5043503140 @default.
- W2894528081 creator A5076381576 @default.
- W2894528081 date "2018-09-25" @default.
- W2894528081 modified "2023-10-14" @default.
- W2894528081 title "The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease" @default.
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